Platelet corrected count increments by apheresis platform

BACKGROUND Automated blood collection platforms use different technological systems to isolate and collect individual blood components. These unique systems could potentially result in differences in platelet in vivo viability, as measured by the corrected count increment (CCI). STUDY DESIGN AND MET...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2016-10, Vol.56 (10), p.2584-2586
Main Authors: Tobian, Aaron A.R., King, Karen E., Borge, Prabhakar D., Fuller, Alice K., Uglik, Kristin, Ness, Paul M.
Format: Article
Language:English
Subjects:
Automation
Blood platelets
Blood Platelets - cytology
Cell Survival
Humans
Platelet Count - methods
Platelet Transfusion - methods
Platelet Transfusion - standards
Plateletpheresis - instrumentation
Plateletpheresis - methods
Plateletpheresis - standards
Retrospective Studies
Standard deviation
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Summary:BACKGROUND Automated blood collection platforms use different technological systems to isolate and collect individual blood components. These unique systems could potentially result in differences in platelet in vivo viability, as measured by the corrected count increment (CCI). STUDY DESIGN AND METHODS This retrospective study evaluated CCI data of platelet transfusions among oncology patients who received multiple unmanipulated apheresis platelets between January 1, 2006 and December 31, 2009. Apheresis platelets were collected from our community blood center by standard procedures using two different collection systems and were transfused to patients in a blinded manner. RESULTS The CCI of the platelet recipient was significantly higher at 0‐2 hours post‐transfusion among the individuals who received platelets collected on Trima Accel (Terumo BCT) (mean = 6281, standard deviation = 3650) compared to the platelets collected by the Amicus system (Fresenius Kabi) (mean = 5251, standard deviation = 3311, p = 0.004). CONCLUSIONS These hypothesis‐generating data suggesting improved recovery and survival of Trima Accel platelets demonstrate the need for the investigation and implementation of the best collection methods to provide better platelet transfusion support.
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.13788