Comparison of Two Parathyroid Hormone Assays in Hemodialysis Patients

Parathyroid hormone (PTH) determination is essential for the diagnosis of renal osteodystrophy, but differences between the laboratory assays can lead to different therapies. This study compared the new Tosoh ST AIA‐Pack Intact PTH assay (Tosoh Bioscience, San Francisco, CA, USA) with the Elecsys In...

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Bibliographic Details
Published in:Artificial organs 2016-10, Vol.40 (10), p.1013-1016
Main Authors: Donati, Gabriele, Cianciolo, Giuseppe, Capelli, Irene, Baraldi, Olga, Gambaretto, Camilla, Demelas, Valentina, Marchetti, Antonio, La Manna, Gaetano
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Assays
End-stage renal disease
Female
Hematologic Tests - methods
Hemodialysis
Humans
Kidney Failure, Chronic - blood
Male
Middle Aged
Parathyroid hormone
Parathyroid Hormone - blood
Renal Dialysis
Vitamin D
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Summary:Parathyroid hormone (PTH) determination is essential for the diagnosis of renal osteodystrophy, but differences between the laboratory assays can lead to different therapies. This study compared the new Tosoh ST AIA‐Pack Intact PTH assay (Tosoh Bioscience, San Francisco, CA, USA) with the Elecsys Intact PTH Roche assay (Roche Diagnostics GmbH, Mannheim, Germany), currently considered the gold standard. Nineteen chronic stable hemodialysis patients were enrolled to check PTH levels with the two assays. Median age was 71 years (range 26–84), M/F = 10/9. Blood samples were taken before the start of the same midweek dialysis session. Two blood vacuettes were collected and immediately transported to the central laboratory. The median PTH value was 268 (range 35–901 pg/dL) with the AIA‐Pack versus 184 (range 39–552 pg/dL) with Elecsys. The Wilcoxon test showed a significant difference between the two methods (P 
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.12661