Hypothesis Driven versus Hypothesis-free: Filling the Gaps in CoQ Biosynthesis

Two independent investigations based on the power of yeast genetics, but using radically different discovery-driven approaches, have solved a long-pursued goal: the understanding of the early steps in CoQ biosynthesis, which may help diagnose CoQ deficiencies of unknown origin (Payet et al., 2016; S...

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Bibliographic Details
Published in:Cell metabolism 2016-10, Vol.24 (4), p.525-526
Main Authors: Enríquez, José Antonio, Sánchez-Cabo, Fátima, Vázquez, Jesús
Format: Article
Language:English
Subjects:
Ataxia
Mitochondrial Diseases
Muscle Weakness
Ubiquinone
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Summary:Two independent investigations based on the power of yeast genetics, but using radically different discovery-driven approaches, have solved a long-pursued goal: the understanding of the early steps in CoQ biosynthesis, which may help diagnose CoQ deficiencies of unknown origin (Payet et al., 2016; Stefely et al., 2016). Two independent investigations based on the power of yeast genetics, but using radically different discovery-driven approaches, have solved a long-pursued goal: the understanding of the early steps in CoQ biosynthesis, which may help diagnose CoQ deficiencies of unknown origin (Payet et al. and Stefely et al.).
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2016.09.021