Systemic mastocytosis with generalised skin involvement

Bone marrow aspirate and biopsy specimen revealed spindle-shaped mast cells co-expressing CD2 and CD25 involving 10% of the bone marrow biopsy cells, as well as a KIT D816V mutation specific for mastocytosis, which led to our diagnosis of systemic mastocytosis with severe skin involvement.

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Bibliographic Details
Published in:The Lancet (British edition) 2017-03, Vol.389 (10072), p.940-940
Main Authors: Zink, Alexander, Dr, Böhner, Alexander, MD, Schuch, Anna, MD, Biedermann, Tilo, Prof, Brockow, Knut, Prof
Format: Article
Language:English
Subjects:
Bone marrow
Humans
Internal Medicine
Leukocytes
Male
Mastocytosis, Systemic - complications
Mastocytosis, Systemic - pathology
Medical diagnosis
Middle Aged
Skin
Skin diseases
Skin Diseases - etiology
Skin Diseases - pathology
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Description
Summary:Bone marrow aspirate and biopsy specimen revealed spindle-shaped mast cells co-expressing CD2 and CD25 involving 10% of the bone marrow biopsy cells, as well as a KIT D816V mutation specific for mastocytosis, which led to our diagnosis of systemic mastocytosis with severe skin involvement.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(16)31710-X