Systemic mastocytosis with generalised skin involvement

Bone marrow aspirate and biopsy specimen revealed spindle-shaped mast cells co-expressing CD2 and CD25 involving 10% of the bone marrow biopsy cells, as well as a KIT D816V mutation specific for mastocytosis, which led to our diagnosis of systemic mastocytosis with severe skin involvement.

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Published in:The Lancet (British edition) 2017-03, Vol.389 (10072), p.940-940
Main Authors: Zink, Alexander, Dr, Böhner, Alexander, MD, Schuch, Anna, MD, Biedermann, Tilo, Prof, Brockow, Knut, Prof
Format: Article
Language:English
Subjects:
Bone marrow
Humans
Internal Medicine
Leukocytes
Male
Mastocytosis, Systemic - complications
Mastocytosis, Systemic - pathology
Medical diagnosis
Middle Aged
Skin
Skin diseases
Skin Diseases - etiology
Skin Diseases - pathology
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container_issue 10072
container_start_page 940
container_title The Lancet (British edition)
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creator Zink, Alexander, Dr
Böhner, Alexander, MD
Schuch, Anna, MD
Biedermann, Tilo, Prof
Brockow, Knut, Prof
description Bone marrow aspirate and biopsy specimen revealed spindle-shaped mast cells co-expressing CD2 and CD25 involving 10% of the bone marrow biopsy cells, as well as a KIT D816V mutation specific for mastocytosis, which led to our diagnosis of systemic mastocytosis with severe skin involvement.
doi_str_mv 10.1016/S0140-6736(16)31710-X
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1474-547X
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source ScienceDirect Journals
subjects Bone marrow
Humans
Internal Medicine
Leukocytes
Male
Mastocytosis, Systemic - complications
Mastocytosis, Systemic - pathology
Medical diagnosis
Middle Aged
Skin
Skin diseases
Skin Diseases - etiology
Skin Diseases - pathology
title Systemic mastocytosis with generalised skin involvement
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