Comparative Outcomes after Haploidentical or Unrelated Donor Bone Marrow or Blood Stem Cell Transplantation in Adult Patients with Hematological Malignancies

Highlights • Haploidentical and unrelated donor transplantation have similar risks of acute and chronic graft-versus-host disease • Haploidentical and unrelated donor recipients have similar probabilities of survival • Human Herpesvirus-6 reactivation is higher for haploidentical transplant recipien...

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Bibliographic Details
Published in:Biology of blood and marrow transplantation 2016-11, Vol.22 (11), p.2047-2055
Main Authors: Baker, Melissa, Wang, Hongkun, Rowley, Scott D, Cai, Ling, Pecora, Andrew L, Skarbnik, Alan, Vesole, David H, Adler-Brecher, Barbara, Kim, Daniel, Donato, Michele L
Format: Article
Language:English
Subjects:
Adult
Aged
Bone Marrow Transplantation - adverse effects
Bone Marrow Transplantation - methods
Bone Marrow Transplantation - mortality
Chimerism
Cyclophosphamide - therapeutic use
Female
Graft Survival
Graft vs Host Disease - prevention & control
Haploidentical transplantation
Hematologic Neoplasms - complications
Hematologic Neoplasms - mortality
Hematologic Neoplasms - therapy
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Peripheral Blood Stem Cell Transplantation - adverse effects
Peripheral Blood Stem Cell Transplantation - methods
Peripheral Blood Stem Cell Transplantation - mortality
Post-transplantation cyclophosphamide
Premedication
Survival Analysis
Transplantation, Haploidentical - adverse effects
Transplantation, Haploidentical - mortality
Treatment Outcome
Unrelated donor transplantation
Unrelated Donors
Virus Activation
Young Adult
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Summary:Highlights • Haploidentical and unrelated donor transplantation have similar risks of acute and chronic graft-versus-host disease • Haploidentical and unrelated donor recipients have similar probabilities of survival • Human Herpesvirus-6 reactivation is higher for haploidentical transplant recipients • Platelet recovery, but not neutrophil recovery, is faster using peripheral blood stem cells for haploidentical transplants • Haploidentical transplantation may achieve more robust early lymphoid engraftment
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2016.08.003