Effect of dietary fish oil on fatty acid deposition and expression of cholesterol homeostasis controlling genes in the liver and plasma lipid profile: comparison of two animal models

• Published in: Journal of animal physiology and animal nutrition 2017-12, Vol.101 (6), p.1093-1102
• Main Authors: Komprda, T, Rozíková, V, Zamazalová, N, Škultéty, O, Vícenová, M, Trčková, M, Faldyna, M
• Format: Article
• Language: English
• Subjects: Acid deposition; Animal Feed - analysis; Animal models; Animal Nutritional Physiological Phenomena; Animals; Cholesterol; Cholesterol - metabolism; Deposition; Diet; Diet - veterinary; Docosahexaenoic acid; Fatty acids; Fatty Acids - metabolism; Fatty liver; Female; Fish; Fish oils; Fish Oils - administration & dosage; Fish Oils - pharmacology; Gene expression; Gene Expression Regulation - drug effects; Genes; High density lipoprotein; Hogs; Homeostasis; Homeostasis - genetics; Homeostasis - physiology; Lipids; Lipids - blood; Liver; long‐chain PUFA n‐3; Low density lipoprotein; Male; Oils & fats; Palm oil; Palmitic acid; Peroxisome proliferator-activated receptors; Pollutant deposition; PPAR α; Rats; Rats, Wistar; Rattus norvegicus; Rodents; Sterol regulatory element-binding protein; Sus scrofa; Swine; Triglycerides; Vegetable oils; Weight Gain - drug effects
• ISSN: 0931-2439; 1439-0396
• DOI: 10.1111/jpn.12581

Summary The objective of the present study was to compare hepatic fatty acid deposition, plasma lipid level and expression of cholesterol homeostasis controlling genes in the liver of rats (Wistar Albino; n = 32) and pigs (Large White × Landrace; n = 32) randomly assigned into two groups of 16 animals each and fed 10 weeks the diet with either 2.5% of fish oil (F; source of eicosapentaenoic and docosahexaenoic acid, EPA+DHA) or 2.5% of palm oil (P; high content of saturated fatty acids; control). F‐rats deposited in the liver three times less EPA, but 1.3 times more DHA than F‐pigs (p