Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats

Cuscuta reflexa Roxb. (Convolvulaceae) is traditionally used to treat diabetes mellitus by tribal people of north-east India and Bangladesh. To evaluate the anti-diabetic effects of methanol and aqueous extracts of the aerial parts of Cuscuta reflexa Roxb. in normal, glucose loaded and Streptozotoci...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2016-11, Vol.192, p.442-449
Main Authors: Rath, Diptirani, Kar, Durga Madhab, Panigrahi, Sandeep Kumar, Maharana, Laxmidhar
Format: Article
Language:English
Subjects:
Animals
Antidiabetic
Biomarkers - blood
Blood Glucose - drug effects
Blood Glucose - metabolism
Blood glucose level
Body Weight - drug effects
Convolvulaceae
Cuscuta - chemistry
Cuscuta - toxicity
Cuscuta reflexa
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
Dose-Response Relationship, Drug
Glycated hemoglobin
Glycated Hemoglobin A - metabolism
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - toxicity
Lipids - blood
Male
Metformin - pharmacology
Methanol - chemistry
Phytotherapy
Plant Components, Aerial - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - toxicity
Plants, Medicinal
Rats
Solvents - chemistry
Streptozocin
Streptozotocin
Time Factors
Water - chemistry
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Summary:Cuscuta reflexa Roxb. (Convolvulaceae) is traditionally used to treat diabetes mellitus by tribal people of north-east India and Bangladesh. To evaluate the anti-diabetic effects of methanol and aqueous extracts of the aerial parts of Cuscuta reflexa Roxb. in normal, glucose loaded and Streptozotocin (STZ) induced diabetic rats. The methanol (MECR) and aqueous (AECR) extracts (200 and 400mg/kg body weight) were administered orally to normal and diabetic rats with Metformin and solvent control as comparison groups. Long term effects like FBG, OGTT, lipid profile, HbA1c, body weight, histopathology of major organs, etc. were investigated. MECR and AECR did not have hypoglycemic effects in normal rats. Both AECR and MECR (400mg/kg) treatments showed significant reduction in blood glucose during OGTT in diabetic rats at 3h. Single oral administration of methanol and aqueous extracts (400mg/kg) to diabetic rats significantly reduced (p
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2016.09.026