Comparison of Donor Sources in Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Nationwide Retrospective Study

Highlights • Outcomes for both unrelated bone marrow transplantation and unrelated cord blood transplantation are currently not statistically inferior to those of identical related bone marrow transplantation • Unrelated cord blood transplantation is useful option for patients with clinical urgent s...

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Bibliographic Details
Published in:Biology of blood and marrow transplantation 2016-12, Vol.22 (12), p.2226-2234
Main Authors: Sakaguchi, Hirotoshi, Watanabe, Nobuhiro, Matsumoto, Kimikazu, Yabe, Hiromasa, Kato, Shunichi, Ogawa, Atsushi, Inagaki, Jiro, Goto, Hiroaki, Koh, Katsuyoshi, Yoshida, Nao, Kato, Keisuke, Cho, Yuko, Kosaka, Yoshiyuki, Takahashi, Yoshiyuki, Inoue, Masami, Kato, Koji, Atsuta, Yoshiko, Miyamura, Koichi
Format: Article
Language:English
Subjects:
Adolescent
Alternative donor
Bone Marrow Transplantation - mortality
Child
Child, Preschool
Childhood acute leukemia
Cord Blood Stem Cell Transplantation - mortality
Hematology, Oncology and Palliative Medicine
Hematopoietic Stem Cell Transplantation - methods
Hematopoietic Stem Cell Transplantation - mortality
Histocompatibility
Humans
Infant
Infant, Newborn
Japan
Male
Myeloablative Agonists - therapeutic use
Nationwide study
Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Retrospective Studies
Survival Analysis
Transplantation Conditioning - methods
Unrelated Donors
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Summary:Highlights • Outcomes for both unrelated bone marrow transplantation and unrelated cord blood transplantation are currently not statistically inferior to those of identical related bone marrow transplantation • Unrelated cord blood transplantation is useful option for patients with clinical urgent situations • New strategies are needed to reduce early transplantation-related mortality after unrelated cord blood transplantation
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2016.09.020