15years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage

Significant improvements in treatment and the understanding of gestational trophoblastic neoplasia have occurred in the last 15years. These diseases are almost always curable, and refractory patients have more options for salvage therapy. Recent improvements in the understanding of epidemiology, dia...

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Bibliographic Details
Published in:Gynecologic oncology 2017-01, Vol.144 (1), p.200-207
Main Authors: Brown, Jubilee, Naumann, R. Wendel, Seckl, Michael J., Schink, Julian
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Choriocarcinoma
Female
Fertility Preservation
Gestational trophoblastic disease
Gestational Trophoblastic Disease - diagnosis
Gestational Trophoblastic Disease - epidemiology
Gestational Trophoblastic Disease - pathology
Gestational Trophoblastic Disease - therapy
Humans
Hydatidiform mole
Hysterectomy
Placental site trophoblastic tumor
Population Surveillance
Pregnancy
Salvage Therapy - methods
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Summary:Significant improvements in treatment and the understanding of gestational trophoblastic neoplasia have occurred in the last 15years. These diseases are almost always curable, and refractory patients have more options for salvage therapy. Recent improvements in the understanding of epidemiology, diagnosis, and cell biology have resulted in changes in staging, advances in treatment options, and opportunities for fertility preservation. •Gestational trophoblastic neoplasia represents a spectrum of diseases with an excellent prognosis.•Outcomes depend on appropriate scoring and treatment.•Fertility preservation is an option for most women with gestational trophoblastic neoplasia.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2016.08.330