Fueling the Cell Division Cycle

Cell division is a complex process with high energy demands. However, how cells regulate the generation of energy required for DNA synthesis and chromosome segregation is not well understood. Recent data suggest that changes in mitochondrial dynamics and metabolic pathways such as oxidative phosphor...

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Bibliographic Details
Published in:Trends in cell biology 2017-01, Vol.27 (1), p.69-81
Main Authors: Salazar-Roa, María, Malumbres, Marcos
Format: Article
Language:English
Subjects:
Animals
Cancer
Cell Cycle
Cell division
Crosstalk
Deoxyribonucleic acid
DNA
DNA biosynthesis
Energy
Energy Metabolism
Glycolysis
Humans
Metabolic pathways
Metabolism
Mitochondria
Mitochondria - metabolism
Mitosis
Models, Biological
Oxidative phosphorylation
Pathology
Phosphorylation
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Summary:Cell division is a complex process with high energy demands. However, how cells regulate the generation of energy required for DNA synthesis and chromosome segregation is not well understood. Recent data suggest that changes in mitochondrial dynamics and metabolic pathways such as oxidative phosphorylation (OXPHOS) and glycolysis crosstalk with, and are tightly regulated by, the cell division machinery. Alterations in energy availability trigger cell-cycle checkpoints, suggesting a bidirectional connection between cell division and general metabolism. Some of these connections are altered in human disease, and their manipulation may help in designing therapeutic strategies for specific diseases including cancer. We review here recent studies describing the control of metabolism by the cell-cycle machinery.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2016.08.009