Respiratory viral infections in a cohort of children during the first year of life and their role in the development of wheezing

• Published in: Anales de pediatría (Barcelona, Spain : 2003) Spain : 2003), 2017-08, Vol.87 (2), p.104-110
• Main Authors: Calvo, Cristina, Aguado, Isabel, García-García, María Luz, Ruiz-Chercoles, Esther, Díaz-Martinez, Eloisa, Albañil, Rosa María, Campelo, Olga, Olivas, Antonio, Muñóz-Gonzalez, Luisa, Pozo, Francisco, Fernandez-Arroyo, Rosa, Fernandez-Rincón, Adelaida, Calderon, Ana, Casas, Inmaculada
• Format: Article
• Language: eng ; spa
• Subjects: Cohort Studies; Female; Humans; Infant; Infant, Newborn; Male; Prospective Studies; Recurrence; Respiratory Sounds - etiology; Respiratory Tract Infections - complications; Respiratory Tract Infections - virology
• ISSN: 1695-9531
• DOI: 10.1016/j.anpedi.2016.08.002

It is known that infants with viral respiratory infections severe enough to require hospital admission have a high risk of developing recurrent wheezing. Few data have been published on unselected populations. The main aim of this study was to analyse symptomatic and asymptomatic respiratory viral infections during the first year of life in a cohort of infants, recruited at birth, and the development of recurrent wheezing. A total of 302 newborns were recruited. A nasopharyngeal aspirate was taken when the patients had a respiratory infection, as well as in the visits for vaccination at 2, 4, 6, and 12 months. RT-nested PCR assays were performed to detect 16 viruses. A total of 1,293 samples were analysed (1,005 healthy controls and 288 respiratory infections). Samples taken during routine check-ups were positive in 30.8% of cases, while those with respiratory infection were positive in 77.8%, P