Quantitative Diffusion Tensor Imaging Analysis of Low-Grade Gliomas: From Preclinical Application to Patient Care

Preoperative diffusion tensor tractography (DTT) has recently been used to aid in the mapping of functional pathways to limit damage associated with resection of low-grade gliomas (LGGs). To assess the predictive capacity of DTT as a biomarker of postoperative motor outcomes in patients with LGGs in...

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Bibliographic Details
Published in:World neurosurgery 2017-01, Vol.97, p.333-343
Main Authors: Ius, Tamara, Turella, Luca, Pauletto, Giada, Isola, Miriam, Maieron, Marta, Sciacca, Giovanni, Budai, Riccardo, D’Agostini, Serena, Eleopra, Roberto, Skrap, Miran
Format: Article
Language:English
Subjects:
Adult
Aged
Brain mapping
Brain Neoplasms - epidemiology
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Comorbidity
Diffusion Tensor Imaging - statistics & numerical data
Diffusion tensor imaging analysis
Early Diagnosis
Extent of resection
Female
Glioma - epidemiology
Glioma - pathology
Glioma - surgery
Humans
Intraoperative electric stimulation
Italy - epidemiology
Low-grade gliomas
Male
Middle Aged
Motor evoked potentials
Movement Disorders - diagnosis
Movement Disorders - epidemiology
Movement Disorders - prevention & control
Neoplasm Grading
Patient-Centered Care - methods
Postoperative Complications - diagnosis
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Preoperative Care
Prevalence
Prognosis
Reproducibility of Results
Retrospective Studies
Risk Factors
Sensitivity and Specificity
White Matter - diagnostic imaging
White Matter - pathology
Young Adult
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Summary:Preoperative diffusion tensor tractography (DTT) has recently been used to aid in the mapping of functional pathways to limit damage associated with resection of low-grade gliomas (LGGs). To assess the predictive capacity of DTT as a biomarker of postoperative motor outcomes in patients with LGGs involving the corticospinal tract (CST). CST parameters obtained using a quantitative fiber tracking approach were used to investigate the reliability of the DTT biomarker by comparing their values in the tumoral (Tcst) and healthy (Hcst) hemispheres. Thirty-seven patients with LGGs involving the CST were enrolled. Quantification of structural differences between the Tcst and Hcst were analyzed according to the novel biomarker (NF index), defined as follows: (Hcst NF – Tcst NF)/Hcst NF, where NF represents the number of fibers in each region. Logistic regression analysis was used to examine associations among clinical postoperative outcomes and NF index values, tumoral patterns, and premotor/motor evoked potentials. NF values significantly differed between the Tcst and Hcst. Analysis of the NF index showed that patients with a preoperative NF index
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2016.10.006