Palladium-Catalyzed Decarboxylative Synthesis of Arylamines

A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse ar...

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Bibliographic Details
Published in:Organic letters 2016-11, Vol.18 (21), p.5560-5563
Main Authors: Dai, Qipu, Li, Peihe, Ma, Nuannuan, Hu, Changwen
Format: Article
Language:English
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Summary:A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C­(sp2)-N bond under mild conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b02724