Biology and pathogenesis of Naegleria fowleri

Naegleria fowleri is a protist pathogen that can cause lethal brain infection. Despite decades of research, the mortality rate related with primary amoebic meningoencephalitis owing to N. fowleri remains more than 90%. The amoebae pass through the nose to enter the central nervous system killing the...

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Bibliographic Details
Published in:Acta tropica 2016-12, Vol.164, p.375-394
Main Authors: Siddiqui, Ruqaiyyah, Ali, Ibne Karim M., Cope, Jennifer R., Khan, Naveed Ahmed
Format: Article
Language:English
Subjects:
Brain - pathology
Central Nervous System Protozoal Infections - parasitology
Diagnosis
Humans
Muslims
Naegleria fowleri
Nasal irrigation
Pathogenic amoebae
Treatment
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Summary:Naegleria fowleri is a protist pathogen that can cause lethal brain infection. Despite decades of research, the mortality rate related with primary amoebic meningoencephalitis owing to N. fowleri remains more than 90%. The amoebae pass through the nose to enter the central nervous system killing the host within days, making it one of the deadliest opportunistic parasites. Accordingly, we present an up to date review of the biology and pathogenesis of N. fowleri and discuss needs for future research against this fatal infection.
ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2016.09.009