Chromium treatment of depression

Eight patients with refractory mood disorders received chromium supplements and described dramatic improvements in their symptoms and functioning. In several instances, single-blind trials confirmed specificity of response to chromium. Side-effects were rare and mild, and most commonly included enha...

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Bibliographic Details
Published in:The international journal of neuropsychopharmacology 2000-12, Vol.3 (4), p.311-314, Article S146114570000208X
Main Authors: McLeod, Malcolm N., Golden, Robert N.
Format: Article
Language:English
Subjects:
Rapid Communication
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Summary:Eight patients with refractory mood disorders received chromium supplements and described dramatic improvements in their symptoms and functioning. In several instances, single-blind trials confirmed specificity of response to chromium. Side-effects were rare and mild, and most commonly included enhanced dreaming and mild psychomotor activation. To our knowledge, this is the first case series describing the response to chromium monotherapy. The putative antidepressant effects of chromium could be accounted for by enhancement of insulin utilization and related increases in tryptophan availability in the central nervous system, and/or by chromium's effects on norepinephrine release.
ISSN:1461-1457
1469-5111
DOI:10.1017/S146114570000208X