Gender difference in m-CPP challenge test in healthy volunteers

Challenge test with oral m-CPP and placebo were performed in 12 healthy, young volunteers (6 male, 6 female) in a double-blind, placebo-controlled, cross-over study to assess possible gender differences in serotonergic responsivity. Women but not men showed significant prolactin and anxiety increase...

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Bibliographic Details
Published in:The international journal of neuropsychopharmacology 1998-12, Vol.1 (2), p.121-124, Article S1461145798001151
Main Authors: Arató, Mihály, Bagdy, György
Format: Article
Language:English
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Summary:Challenge test with oral m-CPP and placebo were performed in 12 healthy, young volunteers (6 male, 6 female) in a double-blind, placebo-controlled, cross-over study to assess possible gender differences in serotonergic responsivity. Women but not men showed significant prolactin and anxiety increase after administration of 0.25 mg/kg oral m-CPPP. Core temperature increased in both sexes compared to placebo. m-CPP induced significant physical symptoms only in men. Gender differences in serotonergic functions may have clinical significance with regard to differences in rates of some psychiatric disorders between the sexes.
ISSN:1461-1457
1469-5111
DOI:10.1017/S1461145798001151