Alopecia areata: What’s new in epidemiology, pathogenesis, diagnosis, and therapeutic options?

Abstract Alopecia areata (AA) is a common and stressful disorder that results in hair loss, and resistant to treatment in some cases. Experimental and clinical evidence suggests that AA is caused by autoimmune attack against the hair follicles. The precise pathomechanism, however, remains unknown. H...

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Bibliographic Details
Published in:Journal of dermatological science 2017-04, Vol.86 (1), p.3-12
Main Authors: Dainichi, Teruki, MD, PhD, Kabashima, Kenji
Format: Article
Language:English
Subjects:
Administration, Topical
Alopecia areata
Alopecia Areata - diagnosis
Alopecia Areata - epidemiology
Alopecia Areata - etiology
Alopecia Areata - therapy
Autoantibodies - immunology
Autoantigens - immunology
Autoimmune Diseases - diagnosis
Autoimmune Diseases - epidemiology
Autoimmune Diseases - etiology
Autoimmune Diseases - therapy
Autoimmunity
Biomarkers - blood
Chemokines - immunology
Cryotherapy
Dermatology
Dermoscopy
Diagnosis
Epidemiology
Genetics
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Hair Follicle - immunology
Humans
Immunotherapy - methods
Incidence
Phototherapy
Practice Guidelines as Topic
Pulse Therapy, Drug
Quality of Life
T-Lymphocytes, Regulatory - immunology
Treatment
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Description
Summary:Abstract Alopecia areata (AA) is a common and stressful disorder that results in hair loss, and resistant to treatment in some cases. Experimental and clinical evidence suggests that AA is caused by autoimmune attack against the hair follicles. The precise pathomechanism, however, remains unknown. Here, we focus on the recent progress in multidisciplinary approaches to the epidemiology, pathogenesis, and new treatments of AA in 996 publications from January 2010 to July 2016, and provide an overview of the current understanding in clinical management and research directions.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.10.004