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Repeated in vitro fertilization failure: Abnormalities identified in the diagnostic assessment
Investigate the proportion of abnormalities identified on the diagnostic assessment performed after at least two previous failed IVF attempts. Discuss the real benefit of this evaluation. Retrospective descriptive study. Between January 2008 and January 2012, 205 couples with at least two consecutiv...
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| Published in: | Gynécologie, obstétrique & fertilité obstétrique & fertilité, 2016-10, Vol.44 (10), p.565-571 |
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| container_title | Gynécologie, obstétrique & fertilité |
| container_volume | 44 |
| creator | Lambert, M Hocké, C Jimenez, C Frantz, S Papaxanthos, A Creux, H |
| description | Investigate the proportion of abnormalities identified on the diagnostic assessment performed after at least two previous failed IVF attempts. Discuss the real benefit of this evaluation.
Retrospective descriptive study. Between January 2008 and January 2012, 205 couples with at least two consecutive failed IVF attempts had a diagnosis evaluation which consisted in couple's karyotypes; autoimmune and haemostasis biological check-up, pelvic ultrasound-Doppler and hysteroscopy for women.
The main biological anomalies were autoimmune for 23.9% of women: antinuclear antibodies (5.7%), antithyroid peroxidase (11.5%) and antithyroglobulin (8.3%); thrombotic with antiphospholipid antibodies for 8.2% of women (1.4% lupus anticoagulant and 6.8% anticardiolipin antibodies), and heterozygous prothrombin gene mutation for 9.5%. Karyotypes were abnormal for 2.1% of women and 0% of men. Ultrasound-Doppler appeared to be abnormal in 44.7% of cases (pulsatility index of uterine artery≥3 and/or protodiastolic notch), and diagnostic hysteroscopy was abnormal in 14.6% of cases. In order to target the real implantation failure, we compared the groups " |
| doi_str_mv | 10.1016/j.gyobfe.2016.08.006 |
| format | article |
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Retrospective descriptive study. Between January 2008 and January 2012, 205 couples with at least two consecutive failed IVF attempts had a diagnosis evaluation which consisted in couple's karyotypes; autoimmune and haemostasis biological check-up, pelvic ultrasound-Doppler and hysteroscopy for women.
The main biological anomalies were autoimmune for 23.9% of women: antinuclear antibodies (5.7%), antithyroid peroxidase (11.5%) and antithyroglobulin (8.3%); thrombotic with antiphospholipid antibodies for 8.2% of women (1.4% lupus anticoagulant and 6.8% anticardiolipin antibodies), and heterozygous prothrombin gene mutation for 9.5%. Karyotypes were abnormal for 2.1% of women and 0% of men. Ultrasound-Doppler appeared to be abnormal in 44.7% of cases (pulsatility index of uterine artery≥3 and/or protodiastolic notch), and diagnostic hysteroscopy was abnormal in 14.6% of cases. In order to target the real implantation failure, we compared the groups "<8 embryos transferred" versus "≥8 embryos transferred" and "pregnancy after the third or fourth IVF cycle" versus "no pregnancy", but no statistically significant difference was found.
The diagnostic assessment carried out for recurrent IVF failure can detect biological, karyotypic and morphological abnormalities, in the same proportion that in previous studies. Further studies will have to be conducted to evaluate the real impact of these abnormalities in the recurrent implantation failure and the effectiveness of therapeutic care.</description><identifier>EISSN: 1769-6682</identifier><identifier>DOI: 10.1016/j.gyobfe.2016.08.006</identifier><identifier>PMID: 27639435</identifier><language>fre</language><publisher>France</publisher><subject>Adult ; Antibodies, Antinuclear - blood ; Antibodies, Antiphospholipid - blood ; Autoantibodies - blood ; Autoimmune Diseases - complications ; Embryo Implantation ; Embryo Transfer ; Female ; Fertilization in Vitro ; Humans ; Infertility - etiology ; Infertility - genetics ; Iodide Peroxidase - immunology ; Karyotype ; Male ; Mutation ; Pregnancy ; Prothrombin - genetics ; Retrospective Studies ; Treatment Failure</subject><ispartof>Gynécologie, obstétrique & fertilité, 2016-10, Vol.44 (10), p.565-571</ispartof><rights>Copyright © 2016 Elsevier Masson SAS. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27639435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lambert, M</creatorcontrib><creatorcontrib>Hocké, C</creatorcontrib><creatorcontrib>Jimenez, C</creatorcontrib><creatorcontrib>Frantz, S</creatorcontrib><creatorcontrib>Papaxanthos, A</creatorcontrib><creatorcontrib>Creux, H</creatorcontrib><title>Repeated in vitro fertilization failure: Abnormalities identified in the diagnostic assessment</title><title>Gynécologie, obstétrique & fertilité</title><addtitle>Gynecol Obstet Fertil</addtitle><description>Investigate the proportion of abnormalities identified on the diagnostic assessment performed after at least two previous failed IVF attempts. Discuss the real benefit of this evaluation.
Retrospective descriptive study. Between January 2008 and January 2012, 205 couples with at least two consecutive failed IVF attempts had a diagnosis evaluation which consisted in couple's karyotypes; autoimmune and haemostasis biological check-up, pelvic ultrasound-Doppler and hysteroscopy for women.
The main biological anomalies were autoimmune for 23.9% of women: antinuclear antibodies (5.7%), antithyroid peroxidase (11.5%) and antithyroglobulin (8.3%); thrombotic with antiphospholipid antibodies for 8.2% of women (1.4% lupus anticoagulant and 6.8% anticardiolipin antibodies), and heterozygous prothrombin gene mutation for 9.5%. Karyotypes were abnormal for 2.1% of women and 0% of men. Ultrasound-Doppler appeared to be abnormal in 44.7% of cases (pulsatility index of uterine artery≥3 and/or protodiastolic notch), and diagnostic hysteroscopy was abnormal in 14.6% of cases. In order to target the real implantation failure, we compared the groups "<8 embryos transferred" versus "≥8 embryos transferred" and "pregnancy after the third or fourth IVF cycle" versus "no pregnancy", but no statistically significant difference was found.
The diagnostic assessment carried out for recurrent IVF failure can detect biological, karyotypic and morphological abnormalities, in the same proportion that in previous studies. Further studies will have to be conducted to evaluate the real impact of these abnormalities in the recurrent implantation failure and the effectiveness of therapeutic care.</description><subject>Adult</subject><subject>Antibodies, Antinuclear - blood</subject><subject>Antibodies, Antiphospholipid - blood</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune Diseases - complications</subject><subject>Embryo Implantation</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Humans</subject><subject>Infertility - etiology</subject><subject>Infertility - genetics</subject><subject>Iodide Peroxidase - immunology</subject><subject>Karyotype</subject><subject>Male</subject><subject>Mutation</subject><subject>Pregnancy</subject><subject>Prothrombin - genetics</subject><subject>Retrospective Studies</subject><subject>Treatment Failure</subject><issn>1769-6682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNo1kEtLxDAUhYMgzjj6D0SydNOaNG3auBsGXzAgiG4tSXMz3qEvk1QYf70Fx9XhHL5zLxxCrjhLOePydp_uDoNxkGazS1mVMiZPyJKXUiVSVtmCnIewZ3OqRHVGFlkphcpFsSQfrzCCjmAp9vQbox-oAx-xxR8dceip09hOHu7o2vSD73SLESFQtNBHdPhXjJ9ALepdP4SIDdUhQAjdTFyQU6fbAJdHXZH3h_u3zVOyfXl83qy3ychzHpMcioLrigtdaCtdwYRxWWZym5fCcVUpZRrHjBWNkNDYhrO8KcpMWcNlqUojVuTm7-7oh68JQqw7DA20re5hmELNKzF_qKQsZvT6iE6mA1uPHjvtD_X_JuIXPrVlUg</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Lambert, M</creator><creator>Hocké, C</creator><creator>Jimenez, C</creator><creator>Frantz, S</creator><creator>Papaxanthos, A</creator><creator>Creux, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>Repeated in vitro fertilization failure: Abnormalities identified in the diagnostic assessment</title><author>Lambert, M ; Hocké, C ; Jimenez, C ; Frantz, S ; Papaxanthos, A ; Creux, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-4e551a813a5ad6f503bf22b4d473f19899bcf0bd3c36ecdc104c5729db16797b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Antibodies, Antinuclear - blood</topic><topic>Antibodies, Antiphospholipid - blood</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune Diseases - complications</topic><topic>Embryo Implantation</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Humans</topic><topic>Infertility - etiology</topic><topic>Infertility - genetics</topic><topic>Iodide Peroxidase - immunology</topic><topic>Karyotype</topic><topic>Male</topic><topic>Mutation</topic><topic>Pregnancy</topic><topic>Prothrombin - genetics</topic><topic>Retrospective Studies</topic><topic>Treatment Failure</topic><toplevel>online_resources</toplevel><creatorcontrib>Lambert, M</creatorcontrib><creatorcontrib>Hocké, C</creatorcontrib><creatorcontrib>Jimenez, C</creatorcontrib><creatorcontrib>Frantz, S</creatorcontrib><creatorcontrib>Papaxanthos, A</creatorcontrib><creatorcontrib>Creux, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Gynécologie, obstétrique & fertilité</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lambert, M</au><au>Hocké, C</au><au>Jimenez, C</au><au>Frantz, S</au><au>Papaxanthos, A</au><au>Creux, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repeated in vitro fertilization failure: Abnormalities identified in the diagnostic assessment</atitle><jtitle>Gynécologie, obstétrique & fertilité</jtitle><addtitle>Gynecol Obstet Fertil</addtitle><date>2016-10</date><risdate>2016</risdate><volume>44</volume><issue>10</issue><spage>565</spage><epage>571</epage><pages>565-571</pages><eissn>1769-6682</eissn><abstract>Investigate the proportion of abnormalities identified on the diagnostic assessment performed after at least two previous failed IVF attempts. Discuss the real benefit of this evaluation.
Retrospective descriptive study. Between January 2008 and January 2012, 205 couples with at least two consecutive failed IVF attempts had a diagnosis evaluation which consisted in couple's karyotypes; autoimmune and haemostasis biological check-up, pelvic ultrasound-Doppler and hysteroscopy for women.
The main biological anomalies were autoimmune for 23.9% of women: antinuclear antibodies (5.7%), antithyroid peroxidase (11.5%) and antithyroglobulin (8.3%); thrombotic with antiphospholipid antibodies for 8.2% of women (1.4% lupus anticoagulant and 6.8% anticardiolipin antibodies), and heterozygous prothrombin gene mutation for 9.5%. Karyotypes were abnormal for 2.1% of women and 0% of men. Ultrasound-Doppler appeared to be abnormal in 44.7% of cases (pulsatility index of uterine artery≥3 and/or protodiastolic notch), and diagnostic hysteroscopy was abnormal in 14.6% of cases. In order to target the real implantation failure, we compared the groups "<8 embryos transferred" versus "≥8 embryos transferred" and "pregnancy after the third or fourth IVF cycle" versus "no pregnancy", but no statistically significant difference was found.
The diagnostic assessment carried out for recurrent IVF failure can detect biological, karyotypic and morphological abnormalities, in the same proportion that in previous studies. Further studies will have to be conducted to evaluate the real impact of these abnormalities in the recurrent implantation failure and the effectiveness of therapeutic care.</abstract><cop>France</cop><pmid>27639435</pmid><doi>10.1016/j.gyobfe.2016.08.006</doi><tpages>7</tpages></addata></record> |
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| identifier | EISSN: 1769-6682 |
| ispartof | Gynécologie, obstétrique & fertilité, 2016-10, Vol.44 (10), p.565-571 |
| issn | 1769-6682 |
| language | fre |
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| source | Elsevier |
| subjects | Adult Antibodies, Antinuclear - blood Antibodies, Antiphospholipid - blood Autoantibodies - blood Autoimmune Diseases - complications Embryo Implantation Embryo Transfer Female Fertilization in Vitro Humans Infertility - etiology Infertility - genetics Iodide Peroxidase - immunology Karyotype Male Mutation Pregnancy Prothrombin - genetics Retrospective Studies Treatment Failure |
| title | Repeated in vitro fertilization failure: Abnormalities identified in the diagnostic assessment |
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