Asymmetric Induction in Hydroacylation by Cooperative Iminium Ion–Transition-Metal Catalysis

A new strategy for the rhodium-catalyzed enantioselective hydroacylation is described. This has been achieved through the merger of iminium ion catalysis and transition-metal catalysis such that asymmetric induction derives from a readily accessible, inexpensive chiral nonracemic secondary amine cat...

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Bibliographic Details
Published in:Organic letters 2016-11, Vol.18 (21), p.5588-5591
Main Authors: Rastelli, Ettore J, Truong, Ngoc T, Coltart, Don M
Format: Article
Language:English
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Summary:A new strategy for the rhodium-catalyzed enantioselective hydroacylation is described. This has been achieved through the merger of iminium ion catalysis and transition-metal catalysis such that asymmetric induction derives from a readily accessible, inexpensive chiral nonracemic secondary amine catalyst rather than a chiral nonracemic phosphine as is typical of conventional asymmetric hydroacylation methods.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b02825