Recent research progress on preparation and application of N, N, N-trimethyl chitosan

N,N,N-trimethyl chitosan (TMC) is a quaternized chitosan derivative with excellent solubility in aqueous solutions. It has been extensively studied as an absorption enhancer, antibacterial agent and gene vector due to its ability to form complexes with anionic gels or macromoleculars. However, the r...

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Bibliographic Details
Published in:Carbohydrate research 2016-11, Vol.434, p.27-32
Main Authors: Wu, Meiyan, Long, Zhu, Xiao, Huining, Dong, Cuihua
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Application
Chitosan - chemical synthesis
Chitosan - chemistry
Chitosan - pharmacology
Drug Carriers
Environmental Restoration and Remediation
Food Packaging
Humans
Molecular Structure
N, N, N-trimethyl chitosan
Preparation methods
Research progress
Solubility
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Summary:N,N,N-trimethyl chitosan (TMC) is a quaternized chitosan derivative with excellent solubility in aqueous solutions. It has been extensively studied as an absorption enhancer, antibacterial agent and gene vector due to its ability to form complexes with anionic gels or macromoleculars. However, the research which describes the process of TMC preparation and its new applications has not been fully reviewed. In this paper, recent progress regarding different TMC preparation methods and its characterization and application in different fields is presented. Key findings are compared and summarized and some topics for further study are suggested. [Display omitted] •In this review, the properties of N,N,N-trimethyl chitosan (TMC) were fully described.•The preparation methods and applications of TMC were summarized.•Some issues were put forward for further study.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2016.08.002