Genetic regulation of Mycobacterium tuberculosis in a lipid-rich environment

Tuberculosis (TB) remains as one of the leading causes of morbidity and mortality among infectious diseases worldwide. Although lipids (mainly fatty acids and cholesterol) have been reported to play an important role during active and latent infection of M. tuberculosis, there are other molecular as...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2017-11, Vol.55, p.392-402
Main Authors: Aguilar-Ayala, Diana A., Palomino, Juan Carlos, Vandamme, Peter, Martin, Anandi, Gonzalez-y-Merchand, Jorge A.
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Gene Expression Regulation, Bacterial
Granuloma
Humans
Hydrogen-Ion Concentration
Hypoxia
Lipid Metabolism
M. tuberculosis
M. tuberculosis gene expression
M. tuberculosis lipids
M. tuberculosis microenvironments
M. tuberculosis stress responses
Mice
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - metabolism
Stress, Physiological
Tuberculosis - microbiology
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Summary:Tuberculosis (TB) remains as one of the leading causes of morbidity and mortality among infectious diseases worldwide. Although lipids (mainly fatty acids and cholesterol) have been reported to play an important role during active and latent infection of M. tuberculosis, there are other molecular aspects of bacterial response to those substrates that are not fully understood, involving gene regulation background. This review highlights recent insights on pathogen gene expression: regulation during its active growth, during survival in presence of lipids and under variable hostile host microenvironments. We also propose several application options of this knowledge that may contribute for improved TB control. •The role of lipids in the survival and adaptation of M. tuberculosis within different host microenvironments are detailed.•The role of transcriptional factors as modulators that drive lipid metabolism of bacilli for survival is critically valued.•The importance of investigating ncRNAs, and genes related to lipid metabolism during the TB infection is examined.•Some approaches for TB control based on genetic response of M. tuberculosis to a lipid-rich environment are discussed.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2016.10.015