Case Report and Review of the Literature: Cardiomyopathy in a Young Woman on High-Dose Quetiapine

We describe a case of cardiomyopathy due to quetiapine. Atypical antipsychotics are known for their multiple and sometimes dangerous side effects. Various studies showed increased sudden cardiac death and sudden unexpected deaths. Quetiapine can cause tachycardia and QT prolongation, alongside a bro...

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Bibliographic Details
Published in:Cardiovascular toxicology 2017-10, Vol.17 (4), p.478-481
Main Authors: Smolders, David M. E., Smolders, Walter A. P.
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - adverse effects
Antipsychotics
Biomedical and Life Sciences
Biomedicine
Bipolar disorder
Cardiology
Cardiomyopathies - chemically induced
Cardiomyopathies - diagnostic imaging
Cardiomyopathy
Care and treatment
Case reports
Dosage and administration
Electrocardiography
Female
Heart
Heart diseases
Humans
Ivabradine
Literature reviews
Pharmacology/Toxicology
Prolongation
Quetiapine
Quetiapine Fumarate - adverse effects
Schizophrenia
Side effects
Tachycardia
Ultrasound
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Summary:We describe a case of cardiomyopathy due to quetiapine. Atypical antipsychotics are known for their multiple and sometimes dangerous side effects. Various studies showed increased sudden cardiac death and sudden unexpected deaths. Quetiapine can cause tachycardia and QT prolongation, alongside a broad list of other side effects. Cardiomyopathy has been reported, but a causative relation was doubted. We report a case of a 37-year-old woman developing a cardiomyopathy under high doses of quetiapine. Symptoms and ultrasound signs largely recovered in the course of the next months after quetiapine was stopped.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-016-9390-y