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Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats
The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were di...
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| Published in: | Biological & pharmaceutical bulletin 2016/11/01, Vol.39(11), pp.1793-1801 |
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| cited_by | cdi_FETCH-LOGICAL-c773t-be9c89c7da3970010aad3bce0b774647eb689f790331e4529569207889608ac93 |
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| cites | cdi_FETCH-LOGICAL-c773t-be9c89c7da3970010aad3bce0b774647eb689f790331e4529569207889608ac93 |
| container_end_page | 1801 |
| container_issue | 11 |
| container_start_page | 1793 |
| container_title | Biological & pharmaceutical bulletin |
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| creator | Guerra, Gerlane Coelho Bernardo Marília Stefani Souza de Menezes Araújo, Aurigena Antunes de Raimundo Fernandes de Araújo Júnior Caroline Addison Carvalho Xavier de Medeiros |
| description | The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/kg). Twenty-four hours after Zy injection, synovial fluid was collected for total leukocyte counts, blood was collected for biochemical measurements, and synovial tissue was collected for histopathology, immunohistochemistry, immunofluorescence and myeloperoxidase (MPO), malonaldehyde (MDA), and non-protein sulphydryl (NPSH) assays. OLM doses of 15 and 30 mg/kg had protective effects, as evidenced by improved histopathological parameters of synovium, reduced total leukocyte counts, reduced MPO and MDA levels, and increased NPSH group levels compared with the Zy group. OLM reduced immunostaining for cyclooxygenase 2, tumour necrosis factor and interleukin 17 and increased immunostaining for superoxide dismutase and glutathione peroxidase. SD produced similar results. The drugs studied caused no change in biochemical parameters of the animals. OLM showed protective effects in this model of Zy-induced intra-articular inflammation. |
| doi_str_mv | 10.1248/bpb.b16-00296 |
| format | article |
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Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/kg). Twenty-four hours after Zy injection, synovial fluid was collected for total leukocyte counts, blood was collected for biochemical measurements, and synovial tissue was collected for histopathology, immunohistochemistry, immunofluorescence and myeloperoxidase (MPO), malonaldehyde (MDA), and non-protein sulphydryl (NPSH) assays. OLM doses of 15 and 30 mg/kg had protective effects, as evidenced by improved histopathological parameters of synovium, reduced total leukocyte counts, reduced MPO and MDA levels, and increased NPSH group levels compared with the Zy group. OLM reduced immunostaining for cyclooxygenase 2, tumour necrosis factor and interleukin 17 and increased immunostaining for superoxide dismutase and glutathione peroxidase. SD produced similar results. The drugs studied caused no change in biochemical parameters of the animals. OLM showed protective effects in this model of Zy-induced intra-articular inflammation.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b16-00296</identifier><identifier>PMID: 27803450</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Alanine Transaminase - blood ; Angiotensin II Type 1 Receptor Blockers - pharmacology ; Angiotensin II Type 1 Receptor Blockers - therapeutic use ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antihypertensive Agents - pharmacology ; Antihypertensive Agents - therapeutic use ; Antihypertensives ; Arthritis, Experimental - chemically induced ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - metabolism ; Arthritis, Experimental - pathology ; Aspartate Aminotransferases - blood ; Creatinine - blood ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase-2 ; Diclofenac ; Glutathione - metabolism ; Glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Histopathology ; Imidazoles - pharmacology ; Imidazoles - therapeutic use ; Immunofluorescence ; Immunohistochemistry ; Inflammation ; Interleukin 17 ; Interleukin-17 - metabolism ; intra-articular inflammation ; Leukocyte Count ; Male ; Malondialdehyde ; Malondialdehyde - metabolism ; olmesartan ; Peroxidase - metabolism ; Rats ; Rats, Wistar ; Sodium ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Synovial fluid ; Synovial Membrane - drug effects ; Synovial Membrane - metabolism ; Synovial Membrane - pathology ; Synovium ; Tetrazoles - pharmacology ; Tetrazoles - therapeutic use ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - metabolism ; Tumors ; Urea - blood ; Zymosan</subject><ispartof>Biological and Pharmaceutical Bulletin, 2016/11/01, Vol.39(11), pp.1793-1801</ispartof><rights>2016 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c773t-be9c89c7da3970010aad3bce0b774647eb689f790331e4529569207889608ac93</citedby><cites>FETCH-LOGICAL-c773t-be9c89c7da3970010aad3bce0b774647eb689f790331e4529569207889608ac93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27803450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guerra, Gerlane Coelho Bernardo</creatorcontrib><creatorcontrib>Marília Stefani Souza de Menezes</creatorcontrib><creatorcontrib>Araújo, Aurigena Antunes de</creatorcontrib><creatorcontrib>Raimundo Fernandes de Araújo Júnior</creatorcontrib><creatorcontrib>Caroline Addison Carvalho Xavier de Medeiros</creatorcontrib><creatorcontrib>bProgram Post-Graduation in Health and Society / State University of Rio Grande do Norte</creatorcontrib><creatorcontrib>Post Graduation Program in Biological Sciences / Federal University of Rio Grande do Norte</creatorcontrib><creatorcontrib>Department Biophysical and Pharmacology</creatorcontrib><creatorcontrib>Federal University of Rio Grande do Norte</creatorcontrib><creatorcontrib>Post Graduation Program in Health and Society / State University of Rio Grande do Norte</creatorcontrib><creatorcontrib>dPost Graduation Program in Functional and Structural Biology / Post Graduation Program Health Science / Department of Morphology</creatorcontrib><creatorcontrib>Post Graduation Program in Biotechnology RENORBIO</creatorcontrib><creatorcontrib>cPost Graduation Program Public Health/Post Graduation Program in Pharmaceutical Science / Department of Biophysics and Pharmacology</creatorcontrib><creatorcontrib>eDepartment of Biophysics and Pharmacology</creatorcontrib><creatorcontrib>aPost Graduation Program in Biological Sciences / Federal University of Rio Grande do Norte</creatorcontrib><title>Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/kg). Twenty-four hours after Zy injection, synovial fluid was collected for total leukocyte counts, blood was collected for biochemical measurements, and synovial tissue was collected for histopathology, immunohistochemistry, immunofluorescence and myeloperoxidase (MPO), malonaldehyde (MDA), and non-protein sulphydryl (NPSH) assays. OLM doses of 15 and 30 mg/kg had protective effects, as evidenced by improved histopathological parameters of synovium, reduced total leukocyte counts, reduced MPO and MDA levels, and increased NPSH group levels compared with the Zy group. OLM reduced immunostaining for cyclooxygenase 2, tumour necrosis factor and interleukin 17 and increased immunostaining for superoxide dismutase and glutathione peroxidase. SD produced similar results. The drugs studied caused no change in biochemical parameters of the animals. OLM showed protective effects in this model of Zy-induced intra-articular inflammation.</description><subject>Alanine Transaminase - blood</subject><subject>Angiotensin II Type 1 Receptor Blockers - pharmacology</subject><subject>Angiotensin II Type 1 Receptor Blockers - therapeutic use</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antihypertensives</subject><subject>Arthritis, Experimental - chemically induced</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - metabolism</subject><subject>Arthritis, Experimental - pathology</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Creatinine - blood</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cyclooxygenase-2</subject><subject>Diclofenac</subject><subject>Glutathione - metabolism</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Histopathology</subject><subject>Imidazoles - pharmacology</subject><subject>Imidazoles - therapeutic use</subject><subject>Immunofluorescence</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Interleukin 17</subject><subject>Interleukin-17 - metabolism</subject><subject>intra-articular inflammation</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - metabolism</subject><subject>olmesartan</subject><subject>Peroxidase - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Synovial fluid</subject><subject>Synovial Membrane - drug effects</subject><subject>Synovial Membrane - metabolism</subject><subject>Synovial Membrane - pathology</subject><subject>Synovium</subject><subject>Tetrazoles - pharmacology</subject><subject>Tetrazoles - therapeutic use</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumors</subject><subject>Urea - blood</subject><subject>Zymosan</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpdkU1vEzEQhi0EoqFw5IoiceGy7dhefx1RgbZSpKKqXLhYtncCG3m9wd6tlH-Pk5Qg9eLReJ55Z_yakPcULihr9aXf-gtPZQPAjHxBFpS3qhGMipdkAYbqRlKhz8ibUjYAoIDx1-SMKQ28FbAgq7s4YHF5cmn5PeMjpgm75W2asmvqbR_m6HLN19ENg5v6MdWkm0OF_G75czeMpXb2aXnvpvKWvFq7WPDdUzwnP759fbi6aVZ317dXn1dNUIpPjUcTtAmqc9woAArOddwHBK9UK1uFXmqzVgY4p9gKZoQ0DJTWRoJ2wfBz8umou83jnxnLZIe-BIzRJRznYqnmQnBmNK3ox2foZpxzqtvtKcklKKYq1RypkMdSMq7tNveDyztLwe5tttVmW222B5sr_-FJdfYDdif6n68VuD4CtdoHF8cU-4T_Z4eifD_G0TI4iHJDaQ3aUmV43QwoU4Iq2L_1y1FpUyb3C0-jDp8T8bAYN7a21_O04akcfrtsMfG_NWelSw</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Guerra, Gerlane Coelho Bernardo</creator><creator>Marília Stefani Souza de Menezes</creator><creator>Araújo, Aurigena Antunes de</creator><creator>Raimundo Fernandes de Araújo Júnior</creator><creator>Caroline Addison Carvalho Xavier de Medeiros</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats</title><author>Guerra, Gerlane Coelho Bernardo ; Marília Stefani Souza de Menezes ; Araújo, Aurigena Antunes de ; Raimundo Fernandes de Araújo Júnior ; Caroline Addison Carvalho Xavier de Medeiros</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c773t-be9c89c7da3970010aad3bce0b774647eb689f790331e4529569207889608ac93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alanine Transaminase - blood</topic><topic>Angiotensin II Type 1 Receptor Blockers - pharmacology</topic><topic>Angiotensin II Type 1 Receptor Blockers - therapeutic use</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antihypertensives</topic><topic>Arthritis, Experimental - chemically induced</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - metabolism</topic><topic>Arthritis, Experimental - pathology</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Creatinine - blood</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase-2</topic><topic>Diclofenac</topic><topic>Glutathione - metabolism</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Histopathology</topic><topic>Imidazoles - pharmacology</topic><topic>Imidazoles - therapeutic use</topic><topic>Immunofluorescence</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Interleukin 17</topic><topic>Interleukin-17 - metabolism</topic><topic>intra-articular inflammation</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - metabolism</topic><topic>olmesartan</topic><topic>Peroxidase - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Synovial fluid</topic><topic>Synovial Membrane - drug effects</topic><topic>Synovial Membrane - metabolism</topic><topic>Synovial Membrane - pathology</topic><topic>Synovium</topic><topic>Tetrazoles - pharmacology</topic><topic>Tetrazoles - therapeutic use</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumors</topic><topic>Urea - blood</topic><topic>Zymosan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guerra, Gerlane Coelho Bernardo</creatorcontrib><creatorcontrib>Marília Stefani Souza de Menezes</creatorcontrib><creatorcontrib>Araújo, Aurigena Antunes de</creatorcontrib><creatorcontrib>Raimundo Fernandes de Araújo Júnior</creatorcontrib><creatorcontrib>Caroline Addison Carvalho Xavier de Medeiros</creatorcontrib><creatorcontrib>bProgram Post-Graduation in Health and Society / State University of Rio Grande do Norte</creatorcontrib><creatorcontrib>Post Graduation Program in Biological Sciences / Federal University of Rio Grande do Norte</creatorcontrib><creatorcontrib>Department Biophysical and Pharmacology</creatorcontrib><creatorcontrib>Federal University of Rio Grande do Norte</creatorcontrib><creatorcontrib>Post Graduation Program in Health and Society / State University of Rio Grande do Norte</creatorcontrib><creatorcontrib>dPost Graduation Program in Functional and Structural Biology / Post Graduation Program Health Science / Department of Morphology</creatorcontrib><creatorcontrib>Post Graduation Program in Biotechnology RENORBIO</creatorcontrib><creatorcontrib>cPost Graduation Program Public Health/Post Graduation Program in Pharmaceutical Science / Department of Biophysics and Pharmacology</creatorcontrib><creatorcontrib>eDepartment of Biophysics and Pharmacology</creatorcontrib><creatorcontrib>aPost Graduation Program in Biological Sciences / Federal University of Rio Grande do Norte</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guerra, Gerlane Coelho Bernardo</au><au>Marília Stefani Souza de Menezes</au><au>Araújo, Aurigena Antunes de</au><au>Raimundo Fernandes de Araújo Júnior</au><au>Caroline Addison Carvalho Xavier de Medeiros</au><aucorp>bProgram Post-Graduation in Health and Society / State University of Rio Grande do Norte</aucorp><aucorp>Post Graduation Program in Biological Sciences / Federal University of Rio Grande do Norte</aucorp><aucorp>Department Biophysical and Pharmacology</aucorp><aucorp>Federal University of Rio Grande do Norte</aucorp><aucorp>Post Graduation Program in Health and Society / State University of Rio Grande do Norte</aucorp><aucorp>dPost Graduation Program in Functional and Structural Biology / Post Graduation Program Health Science / Department of Morphology</aucorp><aucorp>Post Graduation Program in Biotechnology RENORBIO</aucorp><aucorp>cPost Graduation Program Public Health/Post Graduation Program in Pharmaceutical Science / Department of Biophysics and Pharmacology</aucorp><aucorp>eDepartment of Biophysics and Pharmacology</aucorp><aucorp>aPost Graduation Program in Biological Sciences / Federal University of Rio Grande do Norte</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2016</date><risdate>2016</risdate><volume>39</volume><issue>11</issue><spage>1793</spage><epage>1801</epage><pages>1793-1801</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/kg). Twenty-four hours after Zy injection, synovial fluid was collected for total leukocyte counts, blood was collected for biochemical measurements, and synovial tissue was collected for histopathology, immunohistochemistry, immunofluorescence and myeloperoxidase (MPO), malonaldehyde (MDA), and non-protein sulphydryl (NPSH) assays. OLM doses of 15 and 30 mg/kg had protective effects, as evidenced by improved histopathological parameters of synovium, reduced total leukocyte counts, reduced MPO and MDA levels, and increased NPSH group levels compared with the Zy group. OLM reduced immunostaining for cyclooxygenase 2, tumour necrosis factor and interleukin 17 and increased immunostaining for superoxide dismutase and glutathione peroxidase. SD produced similar results. The drugs studied caused no change in biochemical parameters of the animals. OLM showed protective effects in this model of Zy-induced intra-articular inflammation.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>27803450</pmid><doi>10.1248/bpb.b16-00296</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 2016/11/01, Vol.39(11), pp.1793-1801 |
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| language | eng |
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| source | Free Full-Text Journals in Chemistry |
| subjects | Alanine Transaminase - blood Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 1 Receptor Blockers - therapeutic use Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Antihypertensives Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Aspartate Aminotransferases - blood Creatinine - blood Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Diclofenac Glutathione - metabolism Glutathione peroxidase Glutathione Peroxidase - metabolism Histopathology Imidazoles - pharmacology Imidazoles - therapeutic use Immunofluorescence Immunohistochemistry Inflammation Interleukin 17 Interleukin-17 - metabolism intra-articular inflammation Leukocyte Count Male Malondialdehyde Malondialdehyde - metabolism olmesartan Peroxidase - metabolism Rats Rats, Wistar Sodium Superoxide dismutase Superoxide Dismutase - metabolism Synovial fluid Synovial Membrane - drug effects Synovial Membrane - metabolism Synovial Membrane - pathology Synovium Tetrazoles - pharmacology Tetrazoles - therapeutic use Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumors Urea - blood Zymosan |
| title | Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats |
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