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Expression of activated Notch1 and Hey1 in papillary thyroid carcinoma
Aims The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC). Methods and results We examined the relationship between clinicopathol...
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| Published in: | Histopathology 2017-01, Vol.70 (2), p.301-308 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 308 |
| container_issue | 2 |
| container_start_page | 301 |
| container_title | Histopathology |
| container_volume | 70 |
| creator | Jung, Chang Won Kong, Jun Suk Seol, Hyesil Park, Sunhoo Koh, Jae Soo Lee, Seung‐Sook Kim, Min Joo Choi, Ik Joon Myung, Jae Kyung |
| description | Aims
The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC).
Methods and results
We examined the relationship between clinicopathological factors and the expression of activated Notch1 and Hey1, which are indicators of Notch signalling pathway activation, in 109 PTC cases. Activated Notch1 showed strong, moderate and weak expression in 23, 48 and 36 cases, respectively. Its expression was related significantly to histopathological variants (P = 0.007), lymph node metastasis (P = 0.016), BRAF mutation (P = 0.036) and extent of surgery (P = 0.014). Hey1 immunostaining could be divided into two groups: positive and negative, with 26 and 83 cases, respectively. Its expression was related significantly to histopathological variants (P = 0.026), extrathyroidal extension (P = 0.005), BRAF mutation (P = 0.048) and recurrence or soft tissue metastasis (P = 0.000). Multivariate analysis revealed that tumour size (>1 cm), Hey1 immunoreactivity and the presence of lymph node metastasis were associated significantly with recurrence or soft tissue metastasis (odds ratio = 7.38, 4.28 and 12.00, respectively).
Conclusions
Thus, we found that activation of Notch signalling was correlated significantly with clinicopathological parameters. Therefore, Notch signalling could be a useful prognostic marker in patients with PTC. |
| doi_str_mv | 10.1111/his.13065 |
| format | article |
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The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC).
Methods and results
We examined the relationship between clinicopathological factors and the expression of activated Notch1 and Hey1, which are indicators of Notch signalling pathway activation, in 109 PTC cases. Activated Notch1 showed strong, moderate and weak expression in 23, 48 and 36 cases, respectively. Its expression was related significantly to histopathological variants (P = 0.007), lymph node metastasis (P = 0.016), BRAF mutation (P = 0.036) and extent of surgery (P = 0.014). Hey1 immunostaining could be divided into two groups: positive and negative, with 26 and 83 cases, respectively. Its expression was related significantly to histopathological variants (P = 0.026), extrathyroidal extension (P = 0.005), BRAF mutation (P = 0.048) and recurrence or soft tissue metastasis (P = 0.000). Multivariate analysis revealed that tumour size (>1 cm), Hey1 immunoreactivity and the presence of lymph node metastasis were associated significantly with recurrence or soft tissue metastasis (odds ratio = 7.38, 4.28 and 12.00, respectively).
Conclusions
Thus, we found that activation of Notch signalling was correlated significantly with clinicopathological parameters. Therefore, Notch signalling could be a useful prognostic marker in patients with PTC.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.13065</identifier><identifier>PMID: 27542980</identifier><identifier>CODEN: HISTDD</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>activated Notch1 ; Adult ; Aged ; Basic Helix-Loop-Helix Transcription Factors - analysis ; Basic Helix-Loop-Helix Transcription Factors - biosynthesis ; Biomarkers, Tumor - analysis ; Carcinoma - pathology ; Carcinoma, Papillary ; Cell Cycle Proteins - analysis ; Cell Cycle Proteins - biosynthesis ; Female ; Hey1 ; Humans ; Immunohistochemistry ; Lymphatic system ; Male ; Metastasis ; Middle Aged ; Multivariate analysis ; papillary thyroid carcinoma ; Receptor, Notch1 - analysis ; Receptor, Notch1 - biosynthesis ; Thyroid cancer ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - pathology ; Tissue Array Analysis ; Young Adult</subject><ispartof>Histopathology, 2017-01, Vol.70 (2), p.301-308</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4195-b1cc832a4b33c8ada5d0eb8de61a8cb4e4ecfa91acd7903b9bd50747a8a588053</citedby><cites>FETCH-LOGICAL-c4195-b1cc832a4b33c8ada5d0eb8de61a8cb4e4ecfa91acd7903b9bd50747a8a588053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27542980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Chang Won</creatorcontrib><creatorcontrib>Kong, Jun Suk</creatorcontrib><creatorcontrib>Seol, Hyesil</creatorcontrib><creatorcontrib>Park, Sunhoo</creatorcontrib><creatorcontrib>Koh, Jae Soo</creatorcontrib><creatorcontrib>Lee, Seung‐Sook</creatorcontrib><creatorcontrib>Kim, Min Joo</creatorcontrib><creatorcontrib>Choi, Ik Joon</creatorcontrib><creatorcontrib>Myung, Jae Kyung</creatorcontrib><title>Expression of activated Notch1 and Hey1 in papillary thyroid carcinoma</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC).
Methods and results
We examined the relationship between clinicopathological factors and the expression of activated Notch1 and Hey1, which are indicators of Notch signalling pathway activation, in 109 PTC cases. Activated Notch1 showed strong, moderate and weak expression in 23, 48 and 36 cases, respectively. Its expression was related significantly to histopathological variants (P = 0.007), lymph node metastasis (P = 0.016), BRAF mutation (P = 0.036) and extent of surgery (P = 0.014). Hey1 immunostaining could be divided into two groups: positive and negative, with 26 and 83 cases, respectively. Its expression was related significantly to histopathological variants (P = 0.026), extrathyroidal extension (P = 0.005), BRAF mutation (P = 0.048) and recurrence or soft tissue metastasis (P = 0.000). Multivariate analysis revealed that tumour size (>1 cm), Hey1 immunoreactivity and the presence of lymph node metastasis were associated significantly with recurrence or soft tissue metastasis (odds ratio = 7.38, 4.28 and 12.00, respectively).
Conclusions
Thus, we found that activation of Notch signalling was correlated significantly with clinicopathological parameters. Therefore, Notch signalling could be a useful prognostic marker in patients with PTC.</description><subject>activated Notch1</subject><subject>Adult</subject><subject>Aged</subject><subject>Basic Helix-Loop-Helix Transcription Factors - analysis</subject><subject>Basic Helix-Loop-Helix Transcription Factors - biosynthesis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma, Papillary</subject><subject>Cell Cycle Proteins - analysis</subject><subject>Cell Cycle Proteins - biosynthesis</subject><subject>Female</subject><subject>Hey1</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>papillary thyroid carcinoma</subject><subject>Receptor, Notch1 - analysis</subject><subject>Receptor, Notch1 - biosynthesis</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Tissue Array Analysis</subject><subject>Young Adult</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kLFOwzAURS0EoqUw8APIEgsMae3YTpwRVS1FqmAA5sixHdVVEgc7BfL3uKQwIPGWtxydd98F4BKjKQ4z2xg_xQQl7AiMMUlYFDOWHYMxIiiLEE7SETjzfosQTkkcn4JRnDIaZxyNwXLx2TrtvbENtCUUsjPvotMKPtpObjAUjYIr3WNoGtiK1lSVcD3sNr2zRkEpnDSNrcU5OClF5fXFYU_A63LxMl9F66f7h_ndOpIUZywqsJScxIIWhEgulGAK6YIrnWDBZUE11bIUGRZSpRkiRVYohlKaCi4Y54iRCbgZvK2zbzvtu7w2XuqQqtF253PMCWMkTBzQ6z_o1u5cE9IFivKYZvsTE3A7UNJZ750u89aZOvyYY5Tvy81Dufl3uYG9Ohh3Ra3VL_nTZgBmA_BhKt3_b8pXD8-D8gvnmYKP</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Jung, Chang Won</creator><creator>Kong, Jun Suk</creator><creator>Seol, Hyesil</creator><creator>Park, Sunhoo</creator><creator>Koh, Jae Soo</creator><creator>Lee, Seung‐Sook</creator><creator>Kim, Min Joo</creator><creator>Choi, Ik Joon</creator><creator>Myung, Jae Kyung</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Expression of activated Notch1 and Hey1 in papillary thyroid carcinoma</title><author>Jung, Chang Won ; Kong, Jun Suk ; Seol, Hyesil ; Park, Sunhoo ; Koh, Jae Soo ; Lee, Seung‐Sook ; Kim, Min Joo ; Choi, Ik Joon ; Myung, Jae Kyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4195-b1cc832a4b33c8ada5d0eb8de61a8cb4e4ecfa91acd7903b9bd50747a8a588053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>activated Notch1</topic><topic>Adult</topic><topic>Aged</topic><topic>Basic Helix-Loop-Helix Transcription Factors - analysis</topic><topic>Basic Helix-Loop-Helix Transcription Factors - biosynthesis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma, Papillary</topic><topic>Cell Cycle Proteins - analysis</topic><topic>Cell Cycle Proteins - biosynthesis</topic><topic>Female</topic><topic>Hey1</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>papillary thyroid carcinoma</topic><topic>Receptor, Notch1 - analysis</topic><topic>Receptor, Notch1 - biosynthesis</topic><topic>Thyroid cancer</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Tissue Array Analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Chang Won</creatorcontrib><creatorcontrib>Kong, Jun Suk</creatorcontrib><creatorcontrib>Seol, Hyesil</creatorcontrib><creatorcontrib>Park, Sunhoo</creatorcontrib><creatorcontrib>Koh, Jae Soo</creatorcontrib><creatorcontrib>Lee, Seung‐Sook</creatorcontrib><creatorcontrib>Kim, Min Joo</creatorcontrib><creatorcontrib>Choi, Ik Joon</creatorcontrib><creatorcontrib>Myung, Jae Kyung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Chang Won</au><au>Kong, Jun Suk</au><au>Seol, Hyesil</au><au>Park, Sunhoo</au><au>Koh, Jae Soo</au><au>Lee, Seung‐Sook</au><au>Kim, Min Joo</au><au>Choi, Ik Joon</au><au>Myung, Jae Kyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of activated Notch1 and Hey1 in papillary thyroid carcinoma</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2017-01</date><risdate>2017</risdate><volume>70</volume><issue>2</issue><spage>301</spage><epage>308</epage><pages>301-308</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><coden>HISTDD</coden><abstract>Aims
The Notch signalling pathway is involved in normal development as well as tumorigenesis. However, it is unclear whether Notch activation is related to diverse clinicopathological factors in papillary thyroid carcinoma (PTC).
Methods and results
We examined the relationship between clinicopathological factors and the expression of activated Notch1 and Hey1, which are indicators of Notch signalling pathway activation, in 109 PTC cases. Activated Notch1 showed strong, moderate and weak expression in 23, 48 and 36 cases, respectively. Its expression was related significantly to histopathological variants (P = 0.007), lymph node metastasis (P = 0.016), BRAF mutation (P = 0.036) and extent of surgery (P = 0.014). Hey1 immunostaining could be divided into two groups: positive and negative, with 26 and 83 cases, respectively. Its expression was related significantly to histopathological variants (P = 0.026), extrathyroidal extension (P = 0.005), BRAF mutation (P = 0.048) and recurrence or soft tissue metastasis (P = 0.000). Multivariate analysis revealed that tumour size (>1 cm), Hey1 immunoreactivity and the presence of lymph node metastasis were associated significantly with recurrence or soft tissue metastasis (odds ratio = 7.38, 4.28 and 12.00, respectively).
Conclusions
Thus, we found that activation of Notch signalling was correlated significantly with clinicopathological parameters. Therefore, Notch signalling could be a useful prognostic marker in patients with PTC.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27542980</pmid><doi>10.1111/his.13065</doi><tpages>8</tpages></addata></record> |
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| subjects | activated Notch1 Adult Aged Basic Helix-Loop-Helix Transcription Factors - analysis Basic Helix-Loop-Helix Transcription Factors - biosynthesis Biomarkers, Tumor - analysis Carcinoma - pathology Carcinoma, Papillary Cell Cycle Proteins - analysis Cell Cycle Proteins - biosynthesis Female Hey1 Humans Immunohistochemistry Lymphatic system Male Metastasis Middle Aged Multivariate analysis papillary thyroid carcinoma Receptor, Notch1 - analysis Receptor, Notch1 - biosynthesis Thyroid cancer Thyroid Cancer, Papillary Thyroid Neoplasms - pathology Tissue Array Analysis Young Adult |
| title | Expression of activated Notch1 and Hey1 in papillary thyroid carcinoma |
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