Synthesis of 1,4-Dihydropyridazines from Propargylic Alcohols and Hydrazones via a Cs2CO3-mediated Process

An efficient catalyst-free annulation process between propargylic alcohols and hydrazones has been reported. Under the optimized conditions, a wide variety of propargylic alcohols bearing an aromatic group or an aromatic heterocyclic group and hydrazones were well tolerated to afford the correspondi...

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Bibliographic Details
Published in:Chemistry letters 2016, Vol.45 (8), p.925-927
Main Authors: Ding, Zong-Cang, Yang, Ying, Cai, Shu-Ning, Wen, Jia-Jie, Zhan, Zhuang-Ping
Format: Article
Language:English
Subjects:
Alcohols
Bearing
Catalysts
Chemical reactions
Hydrazones
Organic chemistry
Synthesis
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Summary:An efficient catalyst-free annulation process between propargylic alcohols and hydrazones has been reported. Under the optimized conditions, a wide variety of propargylic alcohols bearing an aromatic group or an aromatic heterocyclic group and hydrazones were well tolerated to afford the corresponding 1,4-dihydropyridazines in moderate to good yields via a Cs2CO3-mediated process.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.160397