Wrinkled-Surface Mediated Reverse Transfection Platform for Highly Efficient, Addressable Gene Delivery

A novel reverse transfection platform, which embraces a wrinkled‐surface, is developed for highly efficient long‐term gene delivery. Since reverse transfection utilizes the contact between cell and substrate, the increase in the contact area between substrate and cells significantly increases the ge...

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Bibliographic Details
Published in:Advanced healthcare materials 2016-08, Vol.5 (16), p.2025-2030
Main Authors: Joo, Hyunwoo, Shin, Jisoo, Cho, Seung-Woo, Kim, Pilnam
Format: Article
Language:English
Subjects:
Contact
Gene Transfer Techniques
Genes
Health care
HeLa Cells
Humans
Multiplexing
Platforms
reverse transfection
self-forming siRNA nanoparticle
Substrates
Surface Properties
wrinkled surface
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Summary:A novel reverse transfection platform, which embraces a wrinkled‐surface, is developed for highly efficient long‐term gene delivery. Since reverse transfection utilizes the contact between cell and substrate, the increase in the contact area between substrate and cells significantly increases the gene delivery rate. Furthermore, by adopting microwell structures, multiplex, addressable delivery of exogenous materials is successfully demonstrated.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201600354