Final step gallium-68 radiolabelling of silica-coated iron oxide nanorods as potential PET/MR multimodal imaging agents

The investigation of iron oxide-based positron emission tomography/magnetic resonance (PET/MR) multimodal imaging agents is an expanding field in which a variety of nanoparticle sizes, shapes, surface coatings and radioisotopes are open for exploration. This study develops iron oxide nanorods which...

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Bibliographic Details
Published in:Faraday discussions 2014-01, Vol.175, p.59-71
Main Authors: Burke, Benjamin P, Baghdadi, Neazar, Clemente, Gonçalo S, Camus, Nathalie, Guillou, Amaury, Kownacka, Alicja E, Domarkas, Juozas, Halime, Zakaria, Tripier, Raphaël, Archibald, Stephen J
Format: Article
Language:English
Subjects:
Coating
Imaging
Iron oxides
Nanorods
Nanostructure
Positron emission
Radiolabelling
Tomography
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Summary:The investigation of iron oxide-based positron emission tomography/magnetic resonance (PET/MR) multimodal imaging agents is an expanding field in which a variety of nanoparticle sizes, shapes, surface coatings and radioisotopes are open for exploration. This study develops iron oxide nanorods which are coated with various mixtures of poly(ethylene glycol) (PEG) and macrocyclic ligand (DO3A) via the formation of a silica layer on the surface. Gallium-68 radiolabelling of the nanorods was carried out in high radiochemical yields (RCY) and their stability in human serum was demonstrated for all constructs, even in the absence of the macrocyclic chelating unit. Further studies were carried out in an attempt to determine the appropriate amount of PEG coating to give optimal properties for future in vivo studies.
ISSN:1359-6640
1364-5498
DOI:10.1039/c4fd00137k