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Solvent free one-pot multi-component synthesis of β-azaarene substituted ketones via a Sn-catalyzed C(sp 3 )–H functionalization of 2-alkylazaarenes
A tin-catalyzed solvent free one-pot multi-component cascade reaction strategy for the direct Michael addition/C(sp 3 )–H functionalization of 2-alkylazaarenes with aldehydes and ketones via an aldol reaction has been developed. This is the first report and provides cost effective new access to pote...
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Published in: | RSC advances 2015-01, Vol.5 (125), p.103091-103094 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A tin-catalyzed solvent free one-pot multi-component cascade reaction strategy for the direct Michael addition/C(sp
3
)–H functionalization of 2-alkylazaarenes with aldehydes and ketones
via
an aldol reaction has been developed. This is the first report and provides cost effective new access to potent biologically/medicinally important azaarene derivatives with high atom economy. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/C5RA20728B |