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Solvent free one-pot multi-component synthesis of β-azaarene substituted ketones via a Sn-catalyzed C(sp 3 )–H functionalization of 2-alkylazaarenes

A tin-catalyzed solvent free one-pot multi-component cascade reaction strategy for the direct Michael addition/C(sp 3 )–H functionalization of 2-alkylazaarenes with aldehydes and ketones via an aldol reaction has been developed. This is the first report and provides cost effective new access to pote...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (125), p.103091-103094
Main Authors: Chavan, Santosh S., Pathan, Mohsinkhan Y., Mulla, Shafeek A. R.
Format: Article
Language:English
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Summary:A tin-catalyzed solvent free one-pot multi-component cascade reaction strategy for the direct Michael addition/C(sp 3 )–H functionalization of 2-alkylazaarenes with aldehydes and ketones via an aldol reaction has been developed. This is the first report and provides cost effective new access to potent biologically/medicinally important azaarene derivatives with high atom economy.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA20728B