Design and Self-Assembly of a Leucine-Enkephalin Analogue in Different Nanostructures: Application of Nanovesicles

An opioid (leucine‐enkephalin) conformational analogue forms diverse nanostructures such as vesicles, tubes, and organogels through self‐assembly. The nanovesicles encapsulate the natural hydrophobic drug curcumin and allow the controlled release through cation‐generated porogens in membrane mimetic...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2012-04, Vol.8 (7), p.984-990
Main Authors: Koley, Pradyot, Gayen, Anindita, Drew, Michael G. B., Mukhopadhyay, Chaitali, Pramanik, Animesh
Format: Article
Language:English
Subjects:
Analogue
Controlled release
curcumin
Curcumin - administration & dosage
Curcumin - chemistry
Drug Carriers - chemistry
Encapsulation
Enkephalin, Leucine - chemistry
leucine-enkephalin
Microscopy, Atomic Force
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Microscopy, Fluorescence
Nanostructure
nanostructures
Nanostructures - chemistry
Nanostructures - ultrastructure
Nanotechnology
Nanotechnology - methods
responsive materials
Self assembly
Solvents
Tubes
Vesicles
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Summary:An opioid (leucine‐enkephalin) conformational analogue forms diverse nanostructures such as vesicles, tubes, and organogels through self‐assembly. The nanovesicles encapsulate the natural hydrophobic drug curcumin and allow the controlled release through cation‐generated porogens in membrane mimetic solvent.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201101685