Tumors set time

Lung tumors in mice distally alter circadian cycling of transcripts and metabolites in the liver The field of cancer research has expanded from merely observing cancer in isolation to studying it as a systemic phenomenon. Tumors occupy “environments” where they actively interact with multiple cellul...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2016-09, Vol.353 (6303), p.987-988
Main Authors: Shakhmantsir, Iryna, Sehgal, Amita
Format: Article
Language:English
Subjects:
Cancer
Circadian rhythm
Circadian rhythms
Cycles
Humans
Neoplasms
Oligonucleotide Array Sequence Analysis
Oncology
Organs
Pathways
PERSPECTIVES
Tumors
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Summary:Lung tumors in mice distally alter circadian cycling of transcripts and metabolites in the liver The field of cancer research has expanded from merely observing cancer in isolation to studying it as a systemic phenomenon. Tumors occupy “environments” where they actively interact with multiple cellular processes, signaling pathways, and homeostatic mechanisms, such as, according to a recent study by Masri et al. ( 1 ), circadian rhythms. Tumor-secreted molecular messengers (the secretome) can spread over a range of distances and have both short-range and systemic influences on normal tissues and organs ( 2 ). To highlight the systemic effects of the cancer secretome, the concept of tumor “macroenvironment” has been coined ( 3 ). Masri et al. took this “macro” approach to inquire how tumors affect circadian cycling in a distal organ not yet infiltrated by metastasis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aai7631