Synthesis and in vitro antibacterial and antifungal evaluation of quinoline analogue azetidin and thiazolidin derivatives

A library of quinoline analog two novel series of azetidin (SH sub( 1-5)) and thiazolidin (SH sub( a-e)) derivatives were designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds were elucidated with the aid of elemental analysis, IR, super( 1)H-NMR, and m...

Full description

Saved in:
Bibliographic Details
Published in:International letters of chemistry, physics and astronomy physics and astronomy, 2014-01, Vol.20 (2), p.195-195
Main Authors: Prajapati, Shraddha M, Vekariya, Rajesh H, Patel, Kinjal D, Panchal, Shyamali N, Patel, Hitesh D, Rajani, Dhanji P, Rajani, Smita
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Aspergillus niger
Bacteria
Candida
Candida albicans
Derivatives
Escherichia coli
In vitro testing
Pseudomonas aeruginosa
Quinoline
Staphylococcus aureus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A library of quinoline analog two novel series of azetidin (SH sub( 1-5)) and thiazolidin (SH sub( a-e)) derivatives were designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds were elucidated with the aid of elemental analysis, IR, super( 1)H-NMR, and mass spectral data. These novel synthesized compounds were evaluated for antibacterial activity against two gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus) and two gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also studied for their antifungal activity with Candida albicans, Aspergillus niger, and Aspergillus clavatus using the broth dilution technique. Most of the compounds were the best bio-active desired antibacterial analog with less MIC value against different tested strains.
ISSN:2299-3843