Synthesis and antimicrobial activity of coumarinyl Schiff base derivatives

The authors have reported some novel N'-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The...

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Bibliographic Details
Published in:International letters of chemistry, physics and astronomy physics and astronomy, 2014-01, Vol.11 (3), p.193-193
Main Authors: Mishra, Arun, Rathod, Jaynt, Namera, Dipti, Thakrar, Shailesh, Shah, Anamik
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Astronomy
Bacteria
Benzaldehyde
Derivatives
Enterobacter
Escherichia coli
Methyl alcohol
Nuclear magnetic resonance
Pseudomonas aeruginosa
Staphylococcus aureus
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Summary:The authors have reported some novel N'-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of all synthesized compounds are well characterized by Mass, FT-IR, super( 1)H NMR, super( 13)C NMR and elemental analysis. Moreover, all synthesized compounds were screened for in vitro antimicrobial activity against the gram positive (Staphylococcus aureus, Bacilluas subtilis) and gram negative (Escherichia coli, P. aeruginosa, K. pneunonae, Enterobacter) bacterial strain. In which, some of the compounds show potential inhibition against the test organisms.
ISSN:2299-3843