Relationships and redundancies of selected hemodynamic and structural parameters for characterizing virtual treatment of cerebral aneurysms with flow diverter devices

Abstract Background and purpose To quantify the relationship and to demonstrate redundancies between hemodynamic and structural parameters before and after virtual treatment with a flow diverter device (FDD) in cerebral aneurysms. Methods Steady computational fluid dynamics (CFD) simulations were pe...

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Bibliographic Details
Published in:Journal of biomechanics 2016-07, Vol.49 (11), p.2112-2117
Main Authors: Karmonik, C, Anderson, J.R, Beilner, J, Ge, J.J, Partovi, S, Klucznik, R.P, Diaz, O, Zhang, Y.J, Britz, G.W, Grossman, R.G, Lv, N, Huang, Q
Format: Article
Language:English
Subjects:
Aneurysm
Aneurysms
Computational fluid dynamics
Computer Simulation
Correlation
Devices
Diverters
Flow diverter
Hemodynamics
Humans
Hydrodynamics
Intracranial Aneurysm - pathology
Intracranial Aneurysm - physiopathology
Intracranial Aneurysm - therapy
Parents
Physical Medicine and Rehabilitation
Physiology
Pressure
Professional relationships
Redundancy
Simulation
Stents
Velocity
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Summary:Abstract Background and purpose To quantify the relationship and to demonstrate redundancies between hemodynamic and structural parameters before and after virtual treatment with a flow diverter device (FDD) in cerebral aneurysms. Methods Steady computational fluid dynamics (CFD) simulations were performed for 10 cerebral aneurysms where FDD treatment with the SILK device was simulated by virtually reducing the porosity at the aneurysm ostium. Velocity and pressure values proximal and distal to and at the aneurysm ostium as well as inside the aneurysm were quantified. In addition, dome-to-neck ratios and size ratios were determined. Multiple correlation analysis (MCA) and hierarchical cluster analysis (HCA) were conducted to demonstrate dependencies between both structural and hemodynamic parameters. Results Velocities in the aneurysm were reduced by 0.14 m/s on average and correlated significantly ( p
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2015.11.035