High throughput screening for discovery of materials that control stem cell fate

[Display omitted] •An overview of material properties that guide stem cell fate is provided.•The role of high throughput screening for the discovery of materials.•Fabrication of two and three-dimensional screening platforms for cellular interfacing.•Non-exhaustive summary of stem-cell substrates ide...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in solid state & materials science 2016-08, Vol.20 (4), p.202-211
Main Authors: Patel, Asha K., Tibbitt, Mark W., Celiz, Adam D., Davies, Martyn C., Langer, Robert, Denning, Chris, Alexander, Morgan R., Anderson, Daniel G.
Format: Article
Language:English
Subjects:
Biomaterials
Combinatorial analysis
Culture
Differentiation
High throughput screening
Platforms
Regulators
Screening
Stem cells
Topography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •An overview of material properties that guide stem cell fate is provided.•The role of high throughput screening for the discovery of materials.•Fabrication of two and three-dimensional screening platforms for cellular interfacing.•Non-exhaustive summary of stem-cell substrates identified from screens.•Technological hurdles for high throughput materials and cellular characterization. Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior.
ISSN:1359-0286
DOI:10.1016/j.cossms.2016.02.002