Copper-catalyzed cycloaddition between hydrogen phosphonates and activated alkenes: synthesis of phosphonoisoquinolinediones

A new, general method for the synthesis of phosphonoisoquinolinediones has been achieved via copper-catalyzed phosphonation–cyclization of various methacryloylbenzamides with P(O)H compounds. This transformation allows the direct formation of a P–C bond and the construction of an isoquinolinedione r...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (1), p.303-306
Main Authors: Wu, Ju, Gao, Yuzhen, Zhao, Xin, Zhang, Liangliang, Chen, Weizhu, Tang, Guo, Zhao, Yufen
Format: Article
Language:English
Subjects:
Alkenes
Bonding
Construction
Cycloaddition
Formations
Phosphonates
Synthesis
Transformations
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Summary:A new, general method for the synthesis of phosphonoisoquinolinediones has been achieved via copper-catalyzed phosphonation–cyclization of various methacryloylbenzamides with P(O)H compounds. This transformation allows the direct formation of a P–C bond and the construction of an isoquinolinedione ring in one reaction.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA22570A