Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage

Herein we report 22 acedan‐derived, two‐photon fluorophores with synthetic feasibility and full coverage of visible wavelength emission. The emission wavelengths were predicted by computational analysis, which enabled us to visualize multicolor images by two‐photon excitation with single wavelength,...

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Bibliographic Details
Published in:Chemistry : a European journal 2016-09, Vol.22 (40), p.14166-14170
Main Authors: Koo, Ja Young, Heo, Cheol Ho, Shin, Young-Hee, Kim, Dahahm, Lim, Chang Su, Cho, Bong Rae, Kim, Hwan Myung, Park, Seung Bum
Format: Article
Language:English
Subjects:
Accessibility
acedan
biosensors
Brain
Chemical compounds
Chemistry
Color
Computational neuroscience
Design
Design analysis
Emission analysis
Excitation
Feasibility
Feasibility studies
Fluorescence
Fluorophores
Hippocampus
Hydrogen peroxide
Macrophages
Naphthalene
visible color
Wavelength
Wavelengths
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Summary:Herein we report 22 acedan‐derived, two‐photon fluorophores with synthetic feasibility and full coverage of visible wavelength emission. The emission wavelengths were predicted by computational analysis, which enabled us to visualize multicolor images by two‐photon excitation with single wavelength, and to design a turn‐on, two‐photon fluorescence sensor for endogenous H2O2 in Raw 264.7 macrophage and rat brain hippocampus ex vivo. Technicolor detector: Herein, 22 naphthalene‐based two‐photon fluorophores are reported. They are synthetically feasible and have a full coverage of visible color emission wavelengths, which were well‐predicted by computational analysis. A two‐photon fluorophore allows for the visualization of multicolor images by two‐photon excitation with a single wavelength and the rational design of a turn‐on, two‐photon fluorescent sensor for endogenous H2O2 in Raw 264.7 macrophage and rat brain hippocampus, ex vivo.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201603496