Development of hydrocolloid Bi-layer dressing with bio-adhesive and non-adhesive properties

• Published in: Materials Science & Engineering C 2016-12, Vol.69, p.609-615
• Main Authors: Khan, M. Iqbal H., Islam, Jahid M.M., Kabir, Wasifa, Rahman, Ataur, Mizan, Maria, Rahman, M. Fizur, Amin, Jakia, Khan, Mubarak A.
• Format: Article
• Language: English
• Subjects: Adhesives - pharmacology; Anti-Infective Agents - pharmacology; Bacteria - drug effects; Bi-layer film; Biocompatible Materials - pharmacology; Biopolymer blend; Buffers; Calorimetry, Differential Scanning; Chitosan; Chitosan - chemistry; Colloids - pharmacology; Cross-Linking Reagents - chemistry; Crosslinking; Differential scanning calorimetry; Dressing; Fourier transforms; Gelatin; Gelatins; Humans; Infrared spectroscopy; Materials Testing; Microbial Sensitivity Tests; Polyethylene glycol; Polyethylene Glycols - chemistry; Polyvinyl Alcohol - analysis; Spectroscopy, Fourier Transform Infrared; Tensile Strength - drug effects; Wound dressing material
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2016.07.029

Bio-active bi-layer thin film having both bio-adhesive and non-adhesive end composed of polyvinyl alcohol (PVA) and gelatin/chitosan/polyethylene glycol (PEG) blend was developed for biomedical applications especially as an alternative of advanced tissue scaffold. The developed composite film was subjected to mechanical, thermal and physico-chemical characterization such as tensile strength (TS) and elongation at break (Eb), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), fluid drainage capacity and biocompatibility. Suitable packaging was also selected and stability study and aging test of the composite film were performed after packing. The incorporation of chitosan and PEG into gelatin showed improved mechanical properties of both TS and Eb, which suggested the occurrence of interaction among gelatin, chitosan and PEG molecules in the composite film. The presence of crosslinking as an interaction of above three polymers was also confirmed by FTIR study. Results from the DSC study suggested increased thermal stability after crosslinking. On the other hand, water uptake studies suggested excellent fluid drainage capability and hydro-stability of the composite film. The proposed dressing also showed excellent biocompatibility. Based on the studies related to the performance with confirmed identity, we concluded that our developed bi-layer film is very potential as an ideal wound dressing material. [Display omitted] •The developed bio-composite has both bio-adhesive and non-adhesive sides.•Improved mechanical property due to chemical crosslinking•Higher stability in aqueous medium•Higher thermal stability