Numerical simulation of osteocyte cell in response to directional mechanical loadings and mechanotransduction analysis: considering lacunar-canalicular interstitial fluid flow

Highlights • Changes in osteocyte morphology and direction of loadings affects the cell stimulation. • Shear stress in the canaliculi which is along the loading direction is higher than other canaliculi, therefore, these canaliculi play a key role in osteocyte stimulation. • The amount of cell stimu...

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Bibliographic Details
Published in:Computer methods and programs in biomedicine 2016-09, Vol.133, p.133-141
Main Authors: Joukar, Amin, Niroomand-Oscuii, Hanieh, Ghalichi, Farzan
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Bones
Computational fluid dynamics
Directional mechanical loadings
Fluid flow
Fluid–structure interaction (FSI)
Humans
Internal Medicine
Lacunar shape
Lacunar–canalicular interstitial fluid
Mathematical analysis
Mathematical models
Mechanotransduction
Mechanotransduction, Cellular
Osteocyte
Osteocytes - cytology
Other
Shear stress
Stress, Mechanical
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Summary:Highlights • Changes in osteocyte morphology and direction of loadings affects the cell stimulation. • Shear stress in the canaliculi which is along the loading direction is higher than other canaliculi, therefore, these canaliculi play a key role in osteocyte stimulation. • The amount of cell stimulation was shown quantitatively and there was strong dependency between stimulus function, shear stress, calcium, and NO concentration. • Osteocyte cells whose major axis is parallel to the loading direction experienced higher shear stresses than those which were subjected to other loading directions.
ISSN:0169-2607
1872-7565
DOI:10.1016/j.cmpb.2016.05.019