Copper-Catalyzed C-N Bond Formation via Oxidative Cross-Coupling of Amines with [alpha]-Aminocarbonyl Compounds

A novel and selective method for the simple copper-catalyzed [alpha]-amination of [alpha]-aminocarbonyl compounds to afford 2-amino-2-iminocarbonyl and 2-amino-2-oxocarbonyl compounds is reported. This transformation is achieved by C(sp super(3))-H and N-H bond oxidative cross-coupling and selective...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2016-07, Vol.358 (15), p.2385-2391
Main Authors: Liu, Xing-Xing, Wu, Zhao-Yang, He, Yong-Qin, Zhou, Xiao-Qiang, Hu, Ting, Ma, Chao-Wei, Huang, Guo-Sheng
Format: Article
Language:English
Subjects:
Amines
Bonding
Catalysis
Cleavage
Cross coupling
Ketones
Synthesis
Transformations
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel and selective method for the simple copper-catalyzed [alpha]-amination of [alpha]-aminocarbonyl compounds to afford 2-amino-2-iminocarbonyl and 2-amino-2-oxocarbonyl compounds is reported. This transformation is achieved by C(sp super(3))-H and N-H bond oxidative cross-coupling and selective C-N bond oxidative cleavage. This reaction system has a broad reaction scope, providing a facile pathway for the [alpha]-functionalization of [alpha]-amino ketones.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600132