Metal-Organic-Framework-Based Vaccine Platforms for Enhanced Systemic Immune and Memory Response

Nanoparticulate delivery platforms have shown promising advantages for vaccines in many aspects. However, their application was limited so far by lengthy synthetic protocols, the requirement of specific modification of antigen, and by the low efficiency in inducing antigen‐specific cytotoxic T‐lymph...

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Bibliographic Details
Published in:Advanced functional materials 2016-09, Vol.26 (35), p.6454-6461
Main Authors: Zhang, Yan, Wang, Faming, Ju, Enguo, Liu, Zhen, Chen, Zhaowei, Ren, Jinsong, Qu, Xiaogang
Format: Article
Language:English
Subjects:
Antigens
Biomedical materials
CpG ODNs
Drug delivery systems
Immunity
In vitro testing
metal-organic frameworks
ovalbumin
Platforms
Proteins
systemic immunity
Vaccines
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Summary:Nanoparticulate delivery platforms have shown promising advantages for vaccines in many aspects. However, their application was limited so far by lengthy synthetic protocols, the requirement of specific modification of antigen, and by the low efficiency in inducing antigen‐specific cytotoxic T‐lymphocyte responses. This study demonstrates for the first time the construction of metal‐organic‐framework (MOF) based vaccines by encapsulating ovalbumin (OVA) and attaching the cytosine‐phosphate‐guanine oligodeoxynucleotides (CpG ODNs) in/on zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles. The pH responsive decomposition feature enables the system to release the protein antigens and CpG ODNs in the same antigen presenting cells more efficiently. More importantly, in addition to the induction of a potent immune memory response, both in vitro and in vivo experiments show that the vaccines can induce strong humoral and cellular immunity. These findings suggest that the MOF‐based vaccine platforms can be used to produce effective vaccines against a range of ailments, which will facilitate the application of MOFs in biomedical areas. In this paper, metal‐organic‐framework (MOF) based vaccines are fabricated facilely to deliver protein antigens and adjuvants in the same antigen presenting cells. Both in vitro and in vivo experiments demonstrate that the nanocomposites can induce strong humoral, cellular immunity, and potent immune memory response. The MOF‐based vaccine platform can be useful for the prevention and/or therapy of various diseases.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201600650