Encapsulated Conjugated Oligomer Nanoparticles for Real-Time Photoacoustic Sentinel Lymph Node Imaging and Targeted Photothermal Therapy

Noninvasive and nonionizing imaging of sentinel lymph nodes (SLN) is highly desirable for the detection of breast cancer metastasis through sentinel lymph node biopsy. Photoacoustic (PA) imaging is an emerging imaging technique that can serve as a suitable approach for SLN imaging. Herein, novel con...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-09, Vol.12 (35), p.4873-4880
Main Authors: Cai, Xiaolei, Liu, Xiaofeng, Liao, Lun-De, Bandla, Aishwarya, Ling, Ji Min, Liu, Yu-Hang, Thakor, Nitish, Bazan, Guillermo C., Liu, Bin
Format: Article
Language:English
Subjects:
Animals
Biopsy
Breast cancer
Cancer
Cell Line, Tumor
Cell Survival
conjugated oligomer
Hyperthermia, Induced
Imaging
Imaging, Three-Dimensional
Lymph
Lymphatic system
Male
Metastasis
Mice
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanotechnology
NIH 3T3 Cells
Oligomers
organic nanoparticles
photoacoustic imaging
Photoacoustic Techniques - methods
Phototherapy
Photothermal conversion
photothermal therapy
Rats, Wistar
Real time
sentinel lymph node
Sentinel Lymph Node - pathology
Spectrophotometry, Ultraviolet
Temperature
Therapy
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Summary:Noninvasive and nonionizing imaging of sentinel lymph nodes (SLN) is highly desirable for the detection of breast cancer metastasis through sentinel lymph node biopsy. Photoacoustic (PA) imaging is an emerging imaging technique that can serve as a suitable approach for SLN imaging. Herein, novel conjugated oligomer based nanoparticles (NPs) with strong NIR absorption, good biocompatibility, excellent PA contrast, and good photothermal conversion efficiency are reported. Real‐time PA imaging of SLN reveals high resolution of the NPs via injection from the left forepaw pad. In addition, the surface functionalized NPs can target breast cancer cells and kill them efficiently and specifically through photothermal therapy upon 808 nm laser irradiation. This work shows great potential of the nanoparticle PA contrast agent to serve as a multifunctional probe for photothermal therapy at SLNs to achieve the inhibition of cancer cell metastasis in the near future. Encapsulated conjugated oligomer nanoparticles (NPs) with strong NIR absorption are designed for real‐time photoacoustic imaging of sentinel lymph node with high resolution. The surface functionalized NPs also show great ability to kill cancer cells through photothermal effect.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201600697