PhI(OAc) 2 oxidative C5 halogenation of quinolines using copper halides under mild conditions

A concise and efficient protocol for PhI(OAc) 2 oxidation halogenation of quinoline at the C5 position was developed, affording the desired remote C–H activation products in moderate to excellent yields. This reaction proceeds with copper halides as the halogenating reagent to afford the halogenated...

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Bibliographic Details
Published in:RSC advances 2016, Vol.6 (75), p.71485-71488
Main Authors: Liu, Xing-Xing, Wu, Zhao-Yang, Luo, Xin-Liang, He, Yong-Qin, Zhou, Xiao-Qiang, Fan, Yu-Xing, Huang, Guo-Sheng
Format: Article
Language:English
Subjects:
Activation
Copper
Halides
Halogenated
Halogenation
Organic compounds
Reagents
Tolerances
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Summary:A concise and efficient protocol for PhI(OAc) 2 oxidation halogenation of quinoline at the C5 position was developed, affording the desired remote C–H activation products in moderate to excellent yields. This reaction proceeds with copper halides as the halogenating reagent to afford the halogenated quinolines and features excellent substrate tolerance, providing a facile pathway for the C5 halogenation of quinoline.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA14863H