Influence of antiepileptic drugs on serum lipid levels in adult epilepsy patients

Highlights • Use of enzyme-inducing antiepileptic drug caused a marked increase of lipid levels. • Carbamazepine had a strong influence on lipid levels. • Valproic acid decreased HDL cholesterol and increased non-HDL cholesterol. • Increasing age and BMI, and male gender enhanced the risk of dyslipi...

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Bibliographic Details
Published in:Epilepsy research 2016-11, Vol.127, p.101-106
Main Authors: Yamamoto, Yoshiaki, Terada, Kiyohito, Takahashi, Yukitoshi, Imai, Katsumi, Kagawa, Yoshiyuki, Inoue, Yushi
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Biomarkers - blood
Body Mass Index
Carbamazepine
CYP51A1
Dyslipidemia
Dyslipidemias - blood
Dyslipidemias - epidemiology
Enzyme induction
Epilepsy - blood
Epilepsy - drug therapy
Epilepsy - epidemiology
Female
Humans
Lipids - blood
Logistic Models
Male
Middle Aged
Neurology
Pharmacoepidemiology
Retrospective Studies
Risk Factors
Sex Factors
Young Adult
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Summary:Highlights • Use of enzyme-inducing antiepileptic drug caused a marked increase of lipid levels. • Carbamazepine had a strong influence on lipid levels. • Valproic acid decreased HDL cholesterol and increased non-HDL cholesterol. • Increasing age and BMI, and male gender enhanced the risk of dyslipidemia
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2016.08.027