Effects of Melatonin on Differentiation Potential of Ito Cells in Mice with Induced Fibrosis of the Liver

• Published in: Bulletin of experimental biology and medicine 2016-10, Vol.161 (6), p.845-849
• Main Authors: Nalobin, D. S., Suprunenko, E. A., Golichenkov, V. A.
• Format: Article
• Language: English
• Subjects: Actins - genetics; Actins - metabolism; Analysis; Animals; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Carbon Tetrachloride; Cell Biology; Cell Differentiation - drug effects; Crosses, Genetic; Female; Fibronectins; Fibrosis; Gene Expression; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Internal Medicine; Laboratory Medicine; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver Cirrhosis - chemically induced; Liver Cirrhosis - genetics; Liver Cirrhosis - pathology; Liver Cirrhosis - prevention & control; Liver diseases; Liver Regeneration - drug effects; Male; Melatonin; Melatonin - pharmacology; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Morphology and Pathomorphology; Myofibroblasts - drug effects; Myofibroblasts - metabolism; Myofibroblasts - pathology; Pathology; Protective Agents - pharmacology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3526-8

We studied the effects of melatonin on differentiation potential of Ito cells during atypical regeneration of mouse liver under conditions of CCl 4 -induced fibrosis. The dynamics of fibrosis was traced at the histological level and the effects of melatonin on the differentiation potential of mouse Ito cells were evaluated. Melatonin alleviated fibrotic changes in the liver tissue and reduced differentiation of Ito cells into myofibroblasts under conditions of atypical regeneration of the liver in induced fibrosis. The hepatoprotective role of melatonin was shown.