High-resolution-cone beam tomography analysis of bone microarchitecture in patients with acromegaly and radiological vertebral fractures

Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficult occurring even in patients with normal bone mineral density. In this study we evaluated the ability of high-resolution cone-beam computed tomography to provide information on skeletal abnormalities...

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Bibliographic Details
Published in:Endocrine 2016-11, Vol.54 (2), p.532-542
Main Authors: Maffezzoni, Filippo, Maddalo, Michele, Frara, Stefano, Mezzone, Monica, Zorza, Ivan, Baruffaldi, Fabio, Doglietto, Francesco, Mazziotti, Gherardo, Maroldi, Roberto, Giustina, Andrea
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Acromegaly
Acromegaly - diagnostic imaging
Adult
Age
Aged
Bone density
Bone Density - physiology
Bone mineral density
Cancellous bone
Cancellous Bone - diagnostic imaging
Computed tomography
Cone-Beam Computed Tomography - methods
Diabetes
Dual energy X-ray absorptiometry
Endocrinology
Female
Femur
Femur Neck - diagnostic imaging
Fractures
Hip
Humanities and Social Sciences
Humans
Internal Medicine
Lumbar Vertebrae - diagnostic imaging
Male
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Original Article
Porosity
Radius
Radius - diagnostic imaging
Science
Spinal Fractures - diagnostic imaging
Spine (lumbar)
Statistical analysis
Tomography
Vertebrae
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Summary:Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficult occurring even in patients with normal bone mineral density. In this study we evaluated the ability of high-resolution cone-beam computed tomography to provide information on skeletal abnormalities associated with vertebral fractures in acromegaly. 40 patients (24 females, 16 males; median age 57 years, range 25–72) and 21 healthy volunteers (10 females, 11 males; median age 60 years, range: 25–68) were evaluated for trabecular (bone volume/trabecular volume ratio, mean trabecular separation, and mean trabecular thickness) and cortical (thickness and porosity) parameters at distal radius using a high-resolution cone-beam computed tomography system. All acromegaly patients were evaluated for morphometric vertebral fractures and for mineral bone density by dual-energy X-ray absorptiometry at lumbar spine, total hip, femoral neck, and distal radius. Acromegaly patients with vertebral fractures (15 cases) had significantly ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-016-1078-3