Development of symptomatic brain metastases after chemoradiotherapy for stage III non-small cell lung cancer: does the type of chemotherapy regimen matter?

• Published in: Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-11, Vol.101, p.68-75
• Main Authors: Hendriks, Lizza E.L, Brouns, Anita J.W.M, Amini, Mohammad, Uyterlinde, Wilma, Wijsman, Robin, Bussink, Jan, Biesma, Bonne, Oei, S. Bing, Stigt, Jos. A, Bootsma, Gerben P, Belderbos, José S.A, De Ruysscher, Dirk K.M, Van den Heuvel, Michel M, Dingemans, Anne-Marie C
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Agents - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Brain - pathology; Brain Neoplasms - drug therapy; Brain Neoplasms - pathology; Brain Neoplasms - radiotherapy; Brain Neoplasms - secondary; Bridged-Ring Compounds - therapeutic use; Carcinoma, Non-Small-Cell Lung - complications; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - radiotherapy; Chemoradiation; Chemoradiotherapy - methods; Chemotherapy; Cisplatin; Combined Modality Therapy; Etoposide; Female; Hematology, Oncology and Palliative Medicine; Humans; Lung Neoplasms - complications; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Male; Middle Aged; Neoplasm Staging; NSCLC; Pulmonary/Respiratory; Retrospective Studies; Risk Factors; Stage III; Survival Analysis; Symptomatic brain metastases; Taxoids - therapeutic use; Treatment Outcome; Vinblastine - analogs & derivatives; Vinblastine - therapeutic use
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/j.lungcan.2016.09.008

Highlights • 18% of chemoradiation treated stage III NSCLC develop symptomatic brain metastases. • Symptomatic brain metastases development is not dependent on specific chemotherapy. • Other modifiable factors should be studied that reduce brain metastases development