neo-Clerodane Diterpenoids and Other Constituents of Salvia filipes

A series of neo-clerodane-type diterpenoids were isolated from the aerial parts of Salvia filipes, including the new compounds 4-epi-polystachyne A (1), salvifilines A (3), C (7), and D (8), and salvifiline B, which was isolated as the 15-O-methyl derivatives 4/5. In addition, the five known diterpe...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2016-10, Vol.79 (10), p.2667-2673
Main Authors: Maldonado, Emma, Galicia, Leonel, Chávez, Ma. Isabel, Hernández-Ortega, Simón
Format: Article
Language:English
Subjects:
Diterpenes, Clerodane - chemistry
Diterpenes, Clerodane - isolation & purification
Diterpenes, Clerodane - pharmacology
Drug Screening Assays, Antitumor
Humans
Mexico
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Components, Aerial - chemistry
Salvia - chemistry
Triterpenes - chemistry
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Summary:A series of neo-clerodane-type diterpenoids were isolated from the aerial parts of Salvia filipes, including the new compounds 4-epi-polystachyne A (1), salvifilines A (3), C (7), and D (8), and salvifiline B, which was isolated as the 15-O-methyl derivatives 4/5. In addition, the five known diterpenoids (2, 9–12), together with ursolic, oleanolic, and betulinic acids, and the flavone eupatorin were also isolated. The structures were determined by analysis of their spectroscopic data, mainly 1D and 2D NMR. The structure of salvifiline D was confirmed by X-ray analysis. The cytotoxic activities of the diterpenoids were evaluated, but all were inactive against a panel of six human cancer cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.6b00605