Nuclear Overhauser Enhancement-Mediated Magnetization Transfer Imaging in Glioma with Different Progression at 7 T

Glioma is a malignant neoplasm affecting the central nervous system. The conventional approaches to diagnosis, such as T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and contrast-enhanced T1WI, give an oversimplified representation of anatomic structures. Nuclear Overhauser enhancement (NOE...

Full description

Saved in:
Bibliographic Details
Published in:ACS chemical neuroscience 2017-01, Vol.8 (1), p.60-66
Main Authors: Tang, Xiangyong, Dai, Zhuozhi, Xiao, Gang, Yan, Gen, Shen, Zhiwei, Zhang, Tao, Zhang, Guishan, Zhuang, Zerui, Shen, Yuanyu, Zhang, Zhiyan, Hu, Wei, Wu, Renhua
Format: Article
Language:English
Subjects:
Algorithms
Amides - chemistry
Animals
Brain Neoplasms - diagnostic imaging
Disease Models, Animal
Disease Progression
Female
Glioma - diagnostic imaging
Image Processing, Computer-Assisted
Magnetic Resonance Imaging - methods
Protons
Rats
Rats, Sprague-Dawley
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glioma is a malignant neoplasm affecting the central nervous system. The conventional approaches to diagnosis, such as T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and contrast-enhanced T1WI, give an oversimplified representation of anatomic structures. Nuclear Overhauser enhancement (NOE) imaging is a special form of magnetization transfer (MT) that provides a new way to detect small solute pools through indirect measurement of attenuated water signals, and makes it possible to probe semisolid macromolecular protons. In this study, we investigated the correlation between the effect of NOE-mediated imaging and progression of glioma in a rat tumor model. We found that the NOE signal decreased in tumor region, and signal of tumor center and peritumoral normal tissue markedly decreased with growth of the glioma. At the same time, NOE signal in contralateral normal tissue dropped relatively late (at about day 16–20 after implanting the glioma cells). NOE imaging is a new contrast method that may provide helpful insights into the pathophysiology of glioma with regard to mobile proteins, lipids, and other metabolites. Further, NOE images differentiate normal brain tissue from glioma tissue at a molecular level. Our study indicates that NOE-mediated imaging is a new and promising approach for estimation of tumor progression.
ISSN:1948-7193
1948-7193
DOI:10.1021/acschemneuro.6b00173