Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion

The objective of the current study was to investigate the expression pattern of Tbx3 and its clinicopathological significance in patients with gastric cancer. The expression pattern of Tbx3 in gastric cancer tissues and adjacent noncancerous surface epithelia and mucosal glands was detected by immun...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2016-11, Vol.469 (5), p.505-513
Main Authors: Miao, Zhi-Feng, Liu, Xing-Yu, Xu, Hui-Mian, Wang, Zhen-Ning, Zhao, Ting-Ting, Song, Yong-Xi, Xing, Ya-Nan, Huang, Jin-Yu, Zhang, Jun-Yan, Xu, Hao, Xu, Ying-Ying
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
Cell Transformation, Neoplastic - genetics
Epithelial-Mesenchymal Transition
Female
Gene Expression Regulation, Neoplastic - genetics
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Original Article
Pathology
RNA, Small Interfering - genetics
Stomach Neoplasms - diagnosis
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
T-Box Domain Proteins - metabolism
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Summary:The objective of the current study was to investigate the expression pattern of Tbx3 and its clinicopathological significance in patients with gastric cancer. The expression pattern of Tbx3 in gastric cancer tissues and adjacent noncancerous surface epithelia and mucosal glands was detected by immunohistochemistry. Tbx3 was found to be overexpressed in 46 of 98 human gastric cancer samples, and this correlated with advanced clinical stage, tumor stage, and nodal status. In addition, in the SGC-7901 gastric cancer cell line, Tbx3 overexpression by plasmid transfection promoted growth and invasion. Conversely, depleting Tbx3 expression by small-interfering RNA inhibited proliferation and invasion in BGC-823 cell line. Moreover, Tbx3 accelerated cell cycle progression at the G1/S boundary. Tbx3 also regulated epithelial-to-mesenchymal transition (EMT) to promote cell invasion by repressing E-cadherin expression and increasing expression levels N-cadherin, vimentin. These results indicate that in gastric cancer, Tbx3 plays an important role and might be a useful therapy target.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-016-2007-9